| 100% | RADIO | 5 | "Video Killed the ___ Star" (first music video to air on MTV) |
| 77% | RADIO | 5 | "Video Killed the ___ Star" (first music video played on MTV) |
| 75% | STAR | 4 | "Video Killed the Radio ___" (first music video aired on MTV) |
| 75% | RADIO | 5 | "Video Killed the ___ Star" (first video aired on MTV) |
| 69% | RADIO | 5 | "Video Killed the ___ Star" (the first video played on MTV) |
| 66% | STAR | 4 | "Video Killed the Radio ___" (first music video shown on MTV) |
| 65% | RADIO | 5 | "Video Killed the ___ Star" (first video played on MTV) |
| 59% | IRONMAIDEN | 10 | First heavy metal band to have a video air on MTV |
| 59% | PATBENATAR | 10 | Singer whose video for "You Better Run" was the second music video ever aired on MTV (2 wds.) |
| 53% | BOOMBAYAH | 9 | 2020 51-Across song that was the first K-pop debut music video to pass one billion views on YouTube |
| 50% | REALWORLD | 9 | The __; reality TV show, first aired on MTV in '92 |
| 49% | RODSTEWART | 10 | Singer who performed his song "Infatuation" to open the first MTV Video Music Awards, in 1984: 2 wds. |
| 48% | MTV | 3 | Network whose first video was "Video Killed the Radio Star" |
| 48% | MTV | 3 | Channel whose first video was "Video Killed the Radio Star" |
| 47% | BUGGLES | 7 | Band with the first video on MTV, with "the" |
| 47% | KATYPERRY | 9 | "Roar" singer with more than 42 million YouTube subscribers who was the first artist to have multiple music videos reach one billion views on YouTube (2 wds.) |
| 46% | YOUMIGHTTHINK | 13 | The Cars Top 10 hit whose video features 44-Across as a housefly (and was the first to win the MTV Video Music Award for Video of the Year) (3 wds.) |
| 46% | EBERT | 5 | First movie critic to receive a star on the Hollywood Walk of Fame |
| 46% | FLY | 3 | "Learning to ___," Pink Floyd song that won Best Concept Video at the MTV Video Music Awards |
| 46% | EBERT | 5 | The first film critic to receive a star on the Hollywood Walk of Fame |
| 46% | MIDDLEC | 7 | First note learned on the piano, and a homophonic hint to the starred answers |
| 45% | MONEY | 5 | "___ for Nothing," 1985 hit by Dire Straits which was one of the first music videos to feature computer-animated human figures |
| 44% | RHAPSODYRABBIT | 14 | Musical Bugs Bunny animated short introduced by Droopy Dog as the first program to air on 45-Across (2 wds.) |
| 44% | MTV | 3 | Its first song was "Video Killed the Radio Star" |
| 43% | HARRIS | 6 | Stayce, first African American to reach three star general rank in the US Air Force (2016) |
| 43% | GAGA | 4 | "Lady" who wore a meat dress to the MTV Video Music Awards |
| 42% | MAGICAL | 7 | & 7D Film starring, written and co-directed by The Beatles that first aired on BBC TV in 1967 |
| 42% | SOJOURNER | 9 | The first wheeled vehicle to rove on Mars |
| 41% | MISSYELLIOTT | 12 | "Work It" rapper who received the 2019 MTV Video Vanguard Award, the first female rapper to do so: 2 wds. |