| 100% | TEYONAHPARRIS | 13 | "WandaVision" actress who plays art gallery director Brianna in 16-Across: 2 wds. |
| 49% | HOLLYHUNTER | 11 | "The Piano" actress who played Penny in "O Brother, Where Art Thou?": 2 wds. |
| 48% | SONJASOHN | 9 | "Body of Proof" actress who plays GBI Deputy Director Amanda Wagner on 16-Across: 2 wds. |
| 47% | ELIZABETHOLSEN | 14 | "WandaVision" actress who plays Candy Montgomery in "Love and Death": 2 wds. |
| 47% | PENELOPEANN | 11 | With 50-Across, "Carlito's Way" actress who plays the First Lady in 16-Across: 2 wds. |
| 47% | CANDICEBERGEN | 13 | "Murphy Brown" actress who played the pageant director in "Miss Congeniality": 2 wds. |
| 47% | ELLIEKEMPER | 11 | Actress who plays the lead role in 12-/24-Across: 2 wds. |
| 47% | ELIZABETHOLSEN | 14 | "Godzilla" actress who plays Scarlet Witch in "WandaVision": 2 wds. |
| 47% | BETTEMIDLER | 11 | "Beaches" actress who played witch Winnie Sanderson in 29-/30-Across: 2 wds. |
| 46% | JULIANNEMOORE | 13 | "Still Alice" actress who plays 19-Across later in life: 2 wds. |
| 46% | SALLYSTRUTHERS | 14 | Actress who played Archie's daughter Gloria on 16-Across: 2 wds. |
| 46% | KATHRYNHAHN | 11 | "WandaVision" actress who plays Agatha Harkness in the Disney+ spin-off "Agatha All Along": 2 wds. |
| 46% | BARBARAFELDON | 13 | Actress who played Agent 99 on 16-Across: 2 wds. |
| 45% | LEAMICHELE | 10 | Actress who plays 17-Across' girlfriend and was 29-Across' girlfriend in real life: 2 wds. |
| 45% | KATHYNAJIMY | 11 | "Sister Act" actress who played witch Mary Sanderson in 29-/30-Across: 2 wds. |
| 45% | SAOIRSERONAN | 12 | Irish-American actress who played Briony, an aspiring novelist, in 17-Across: 2 wds. |
| 45% | KRISTENSTEWART | 14 | "Twilight" star who plays Sabina in 16-Across: 2 wds. |
| 45% | SANDRADEE | 9 | Actress who played Gidget in 1959: 2 wds. |
| 45% | HAYLEYATWELL | 12 | "Agent Carter" actress who plays 18-Across's wife Evelyn in "Christopher Robin": 2 wds. |
| 45% | JULIECHRISTIE | 13 | "Shampoo" actress who played Lara in the 1965 film version of 19-Across: 2 wds. |
| 45% | MAYARUDOLPH | 11 | "Bridesmaids" actress who plays Christine in 32-Across: 2 wds. |
| 45% | CHARLIZETHERON | 14 | Actress who plays Megyn Kelly in "Bombshell": 2 wds. |
| 45% | NICOLEKIDMAN | 12 | Actress who plays Gretchen Carlson in "Bombshell": 2 wds. |
| 45% | LISAKUDROW | 10 | Actress who plays Phoebe Buffay in "Friends": 2 wds. |
| 45% | JANETLEIGH | 10 | Actress who played Marion Crane in "Psycho": 2 wds. |
| 45% | AMYADAMS | 8 | Actress who played Lynne Cheney in "Vice": 2 wds. |
| 45% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |
| 45% | KRYSTENRITTER | 13 | "Jessica Jones" actress who plays Lucy in the "Echoes" spin-off of 18-Across: 2 wds. |
| 45% | PIPERLAURIE | 11 | "Carrie" actress who played 27-Across's mother in "Children of a Lesser God": 2 wds. |
| 44% | KATHRYNHAHN | 11 | "WandaVision" actress who plays Claire Debella in "Glass Onion" (2 wds.) |