| 100% | BRED | 4 | "What's ___ in the Bone" (second novel in Robertson Davies's Cornish Trilogy) |
| 59% | BUSINESS | 8 | "Fifth ___" (first novel in Robertson Davies's Deptford Trilogy) |
| 45% | APLACE | 6 | 1970 novel by Melvyn Bragg, second in The Cumbrian Trilogy |
| 43% | ECHO | 4 | "An ___ in the Bone" (Diana Gabaldon's seventh "Outlander" novel) |
| 42% | ABANDONED | 9 | Deserted, and the title of the second novel in 27-Across's "Donovan" series |
| 41% | TENDER | 6 | What The Night is in Fitzgerald's 1934 novel |
| 41% | NEWMOON | 7 | Second novel in the "Twilight" series (2 wds.) |
| 40% | HOT | 3 | "___ Fuzz" (2007 police comedy that's the second film in the Cornetto trilogy) |
| 40% | RELOADED | 8 | The Matrix __; second film in the trilogy |
| 40% | SYCAMOREROW | 11 | 2013 best seller that's the second novel in Grisham's Jake Brigance series: 2 wds. |
| 40% | HOT | 3 | "___ Fuzz" (police comedy that's the second film in the "Cornetto Trilogy") |
| 40% | RELOADED | 8 | The Matrix __; second in the trilogy |
| 39% | TIBIA | 5 | Second-largest bone in the body |
| 39% | SERVICE | 7 | The second S in SMS messaging |
| 39% | MAORI | 5 | The people in Keri Hulme's Booker Prize-winning novel "The Bone People" |
| 39% | TIBIA | 5 | Second-longest bone in the human body |
| 39% | KISMET | 6 | What's in the stars |
| 39% | CONTENTS | 8 | What's in the box |
| 39% | NEWS | 4 | What's in the papers |
| 39% | PRINCE | 6 | "___ Caspian: The Return to Narnia," second novel in the fantasy series "The Chronicles of Narnia" by C.S. Lewis |
| 38% | STUPID | 6 | The second S in KISS, "keep it simple, __" |
| 38% | SOVIET | 6 | What the first S in USSR stood for |
| 38% | FORWEAREMANY | 12 | Second novel in the "Bobiverse" science-fiction series by 32-Across (4 wds.) |
| 38% | TIBIA | 5 | Second-longest bone in the body, after the femur |
| 38% | DEES | 4 | What's in the middle of "middle" |
| 38% | VEE | 3 | What's in the middle of Nashville? |
| 38% | TOES | 4 | What's in the five longest answers |
| 38% | GIRLS | 5 | "Kiss the ___," second novel in the Alex Cross series by James Patterson |
| 38% | TWO | 3 | "The ___ Towers," second book in "The Lord of the Rings" trilogy |
| 38% | SKY | 3 | "The Stone ___" (N.K. Jemisin novel in the "Broken Earth" trilogy) |