| 100% | WORST | 5 | "What's the ___ that can happen?" |
| 100% | WORST | 5 | "What's the ___ that could happen?" |
| 97% | SUREWHYNOT | 10 | "Oh, what's the worst that could happen?" |
| 91% | DOIDARE | 7 | ''What's the worst that could happen?'' |
| 66% | THEWORST | 8 | Dr Pepper ad slogan: What's __ that could happen? |
| 66% | TILLYOULOVEME | 13 | Reba McEntire song with the lyric "I guess I can wait if that's what I have to do" |
| 65% | NEWS | 4 | What's happening in the world |
| 65% | EVENT | 5 | That's what happens |
| 65% | CHOOCHOOSTRAIN | 14 | What the Little Engine That Could experienced? |
| 64% | TALE | 4 | Story that could be The Handmaid's |
| 64% | LEAST | 5 | That's the ___ I can do |
| 64% | WHOLEHOG | 8 | With 49-Across, Southern cooking tradition that can be described by the transformation happening in this puzzle |
| 63% | IFS | 3 | What-___ (things that could have happened) |
| 63% | ASIF | 4 | "Like that could happen" |
| 62% | ODDS | 4 | 'What are the ___ of that happening?' |
| 62% | ODDS | 4 | "What are the ___ of that happening?" |
| 62% | RXS | 3 | Items your pharmacist can provide that are just what the doctor ordered, for short |
| 61% | FREE | 4 | What something that's "on the house" is |
| 61% | SOYEAH | 6 | "And, uh, that's what happened" |
| 61% | GATE | 4 | Let's go to the 1930s! What will you see here? The Golden ___ Bridge, landmark in San Francisco that you can see after 1937 |
| 61% | STATEDEBT | 9 | Something that can be collected from anywhere in the U.S.? |
| 61% | AGENDA | 6 | Guide that can become the outline for a meeting's minutes |
| 60% | ETHANOL | 7 | What the first Model T's could run on |
| 60% | SPAM | 4 | Canned meat that's very popular in the Philippines |
| 59% | RELATE | 6 | “I can ___” (“I know what that’s like”) |
| 59% | ASIF | 4 | "Oh, sure, that could really happen!" |
| 59% | POTATOHEAD | 10 | Toy that can be either Mr. or Mrs. ... and what the first part of the answers to starred clues can literally be |
| 59% | HARM | 4 | "What's the ___ in that?" |
| 58% | ODDS | 4 | "What are the ___ of that happening!" (What are the chances) |
| 58% | YOUREMISSINGOUT | 15 | "That's a lost opportunity," and what can be said to the writer of four clues in this puzzle |