| 100% | MAINSTREET | 10 | *It often runs through the center of town |
| 66% | BISECTS | 7 | Runs through the center of |
| 58% | ICHOR | 5 | It ran through the veins of Venus |
| 57% | MISSISSIPPI | 11 | It runs through the middle of the 66-Across |
| 50% | MAIN | 4 | Street name in the center of town |
| 50% | DIAMETER | 8 | Line through the center of a circle |
| 49% | AXIS | 4 | Imaginary line through the center of the Earth |
| 49% | WILLIE | 6 | Wee __ Winkie runs through the town |
| 46% | IRIS | 4 | A pupil is in the center of it |
| 46% | MAIN | 4 | Street through the middle of town |
| 46% | MAINDRAG | 8 | Street through the middle of town |
| 45% | STATELINE | 9 | One runs through the middle of Kansas City |
| 45% | NEPAL | 5 | Its border runs across the summit of Everest |
| 45% | ARE | 3 | It often appears to the right of you |
| 45% | MAIN | 4 | Street through the town square, often |
| 45% | RADII | 5 | Lines that connect the center of a circle to its edge |
| 44% | THREAD | 6 | It may go through the eye of a needle |
| 44% | CHOIR | 5 | It often functions with the help of an organ |
| 44% | RENT | 4 | It often gets paid on the first of the month |
| 43% | TOFU | 4 | It often takes the place of meat in a vegetarian dish |
| 43% | SESS | 4 | It often starts with the striking of a gavel, for short |
| 43% | OHARE | 5 | The Chicago Department of Aviation runs it |
| 43% | AARE | 4 | It flows through the Lake of Thun |
| 43% | BLUEBLOOD | 9 | It flows through the veins of royalty |
| 43% | TEAPARTY | 8 | The Dormouse slept through most of it |
| 43% | ADRENALINE | 10 | It's often part of the rush |
| 43% | LEEDS | 5 | The Aire runs through it |
| 43% | EGYPT | 5 | The Nile runs through it |
| 43% | PISA | 4 | The Arno runs through it |
| 43% | SOUTHSUDAN | 10 | The Nile runs through it |