| 100% | MILA | 4 | ___ 18 (title setting of a 1961 novel) |
| 62% | OTRANTO | 7 | Italian city that is the title setting of a Walpole novel |
| 59% | MAINE | 5 | Setting of many a Stephen King novel |
| 59% | ANTONIA | 7 | Title girl of a Willa Cather novel |
| 59% | LES | 3 | Title beginner of a Victor Hugo novel |
| 59% | EMMA | 4 | Title heroine of a Jane Austen novel |
| 58% | MATILDA | 7 | Title girl of a Dahl novel |
| 58% | RENE | 4 | Title hero of a Chateaubriand novel |
| 58% | EXORCIST | 8 | Title character of a Blatty novel |
| 57% | THE | 3 | With 3-Down, title setting of a 1937 Agatha Christie mystery |
| 56% | SEA | 3 | Title setting for a Hemingway novel, with "the" |
| 55% | ASIA | 4 | Setting of a Kevin Kwan trilogy of novels featuring "crazy rich" people |
| 55% | KITE | 4 | Title toy of a 2003 Khaled Hosseini novel |
| 55% | OTRANTO | 7 | Italian city, setting of a Walpole novel |
| 54% | ANNABEL | 7 | Title girl of a 1906 L. Frank Baum novel |
| 54% | JANEEYRE | 8 | Title governess of a Charlotte Brontë novel: 2 wds. |
| 54% | NADJA | 5 | Title woman of a classic 1928 André Breton novel |
| 52% | DYSTOPIA | 8 | Idea of a bad world, setting for novels like 1984 |
| 51% | DUNCES | 6 | A Confederacy of __, novel set in New Orleans |
| 51% | MAINE | 5 | Portland's state and setting of many a Stephen King novels |
| 49% | WAYSIDESCHOOL | 13 | Setting for a series of novels by 30-Across (2 wds.) |
| 49% | ASLEEP | 6 | English title of a 1989 novel by Banana Yoshimoto |
| 49% | LEE | 3 | Harper —, author of 2015 novel Go Set a Watchman |
| 48% | WHITEOLEANDER | 13 | Janet Fitch coming-of-age novel set in Los Angeles that has a flower in its title (2 wds.) |
| 47% | ARSON | 5 | Setting of a fire maliciously |
| 47% | BABEL | 5 | Setting of a biblical tower |
| 47% | YALTA | 5 | Setting of a 1945 conference |
| 47% | ROAD | 4 | Setting of a fork, perhaps |
| 47% | BOTSWANA | 8 | Setting of the Bessie Head novel “A Question of Power” |
| 46% | COPA | 4 | Setting of a Barry Manilow hit |