| 100% | UPS | 3 | ___ and downs of life |
| 68% | KNEEBENDS | 9 | Ups and downs of exercise? |
| 67% | SEESAW | 6 | The ups and downs of childhood? |
| 67% | LIFE | 4 | "___ Is a Highway," song by Tom Cochrane about driving on a road trip of life full of ups and downs |
| 65% | UPS | 3 | ___ and downs in life |
| 63% | DEATH | 5 | A matter of life and ___ |
| 63% | URGENCY | 7 | Matter of life and death |
| 63% | EBULLIENT | 9 | Full of life and enthusiasm |
| 63% | VIBRANT | 7 | Full of life and vigour |
| 62% | EMER | 4 | Matter of life and death: Abbr. |
| 62% | BIO | 3 | Brief outline of life and work |
| 62% | TIMEINC | 7 | Onetime publisher of Life and People |
| 62% | OSIRIS | 6 | God of life and the afterlife |
| 61% | IRONIES | 7 | Some of life's twists and turns |
| 61% | VIVACIOUS | 9 | Full of life and energy; wildly outgoing |
| 60% | BOBBING | 7 | Up and down motion of boats on waves |
| 60% | LIBERTY | 7 | Life, __ and the pursuit of Happiness |
| 60% | TAYLOR | 6 | 5-Down's partner in life and in "The Taming of the Shrew" |
| 59% | OSIRIS | 6 | God of life, death and fertility who underwent resurrection |
| 59% | IRONMAIDEN | 10 | *"A Matter of Life and Death" heavy metal band |
| 59% | IDEALS | 6 | Life, liberty and the pursuit of happiness |
| 59% | AMERICANDREAM | 13 | Life, liberty and the pursuit of happiness |
| 58% | DONOHARM | 8 | 2014 memoir subtitled "Stories of Life, Death, and Brain Surgery" |
| 58% | BENIGNI | 7 | Director and star of Life is Beautiful: Roberto __ |
| 58% | UPS | 3 | 'Life is full of ___ and downs' |
| 58% | UPS | 3 | "Life is full of ___ and downs." |
| 58% | UPS | 3 | "Life is full of ___ and downs" |
| 58% | UPS | 3 | "Life's full of ___ and downs" |
| 58% | UPS | 3 | "Life is full of ___ and downs..." |