| 100% | LEVAR | 5 | ___ Burton, "Star Trek" actor who appeared on a "Sheldon Cooper Presents: Fun with Flags" segment in "The Big Bang Theory" |
| 41% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 37% | FRANKIEMUNIZ | 12 | "Malcolm in the Middle" actor who was a finalist on season 25 of "Dancing with the Stars" (2 wds.) |
| 36% | GARRETTMORRIS | 13 | "2 Broke Girls" actor who was honored with a star on the Hollywood Walk of Fame in 2023 (2 wds.) |
| 36% | WIL | 3 | Wheaton who starred in The Big Bang Theory |
| 35% | TORI | 4 | Actress Spelling who appeared on "Dancing With the Stars" in 2024 |
| 35% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who guest stars as himself on "The Big Bang Theory" (2 wds.) |
| 35% | JIMPARSONS | 10 | Actor who plays Sheldon on "The Big Bang Theory" (2 wds.) |
| 35% | TAKEI | 5 | "Star Trek" actor George who has had cameos on "The Big Bang Theory" and "King of the Nerds" |
| 35% | JONHAMM | 7 | "Mad Men" actor who appeared on the reality dating show "The Big Date" in 1996: 2 wds. |
| 35% | JIMPARSONS | 10 | "The Big Bang Theory" actor who played Michael in "The Boys in the Band": 2 wds. |
| 34% | ARMITAGE | 8 | Child actor Iain who plays the title role in "The Big Bang Theory" spin-off "Young Sheldon" |
| 34% | BILLNYE | 7 | TV "Science Guy" who appeared on "Dancing With the Stars" in 2013: 2 wds. |
| 34% | WARRENSAPP | 10 | Former NFL player who appeared on "Dancing With the Stars" in 2008: 2 wds. |
| 34% | MICHAELSAM | 10 | Former NFL draft pick who appeared on "Dancing With the Stars" in 2015: 2 wds. |
| 34% | RAJ | 3 | "The Big Bang Theory" friend in a bromance with Howard |
| 34% | CARROLLOCONNOR | 14 | Actor who starred on "All in the Family," a Norman Lear sitcom: 2 wds. |
| 34% | WIL | 3 | Actor Wheaton with a recurring role on "The Big Bang Theory" |
| 33% | CHADOCHOCINCO | 13 | Former name of an NFL player who appeared on "Dancing With the Stars" in 2010: 2 wds. |
| 33% | PARSONS | 7 | Jim who plays Sheldon on The Big Bang Theory |
| 33% | STAN | 4 | ___ Lee, comic book legend who files a restraining order against Sheldon Cooper in "The Big Bang Theory" |
| 33% | WIL | 3 | Actor Wheaton who had a recurring role on "The Big Bang Theory" |
| 32% | ONEAL | 5 | Actor Ryan ___ who got a star on the Hollywood Walk of Fame in 2021 |
| 32% | BAZINGA | 7 | Sheldon Cooper's catchphrase in "The Big Bang Theory" |
| 32% | MAYIMBIALIK | 11 | "The Big Bang Theory" actress who earned a doctorate in neuroscience from 33-Down: 2 wds. |
| 32% | AMY | 3 | ___ Farrah Fowler, neuroscientist from "The Big Bang Theory" who has a Ph.D. in Neurobiology |
| 32% | BRADLEYCOOPER | 13 | Actor who had a song from "A Star Is Born" chart on the Billboard Hot 100 in 2018: 2 wds. |
| 32% | SHELDON | 7 | Who Amy marries in The Big Bang Theory |
| 32% | WIL | 3 | "Star Trek: TNG" actor Wheaton who made several guest appearances on "The Big Bang Theory" |
| 31% | KALEYCUOCO | 10 | "The Big Bang Theory" actress who says "Every trip is a big deal" in Priceline.com commercials (2 wds.) |