| 100% | MADAM | 5 | ___ C. J. Walker, first American woman to become a self-made millionaire, per Guinness |
| 37% | MIRAINAGASU | 11 | First American woman to land a triple axel at the Olympics |
| 32% | WILLA | 5 | ___ Player, first Black woman to become president of a four-year college |
| 31% | LEE | 3 | Rebecca ___ Crumpler (first Black woman to become a medical doctor in the US) |
| 31% | SALLYRIDE | 9 | First American woman to travel into space (1983): 2 wds. |
| 31% | SALLYRIDE | 9 | The first American woman to travel to space |
| 30% | IHOP | 4 | Commercial name that becomes a Native American tribe if you move its first letter to the end |
| 30% | EILEEN | 6 | ___ Collins, American astronaut who became the first woman to command a space shuttle mission in 1999 |
| 30% | RETTON | 6 | First American woman to win the all-around gold in Olympic gymnastics |
| 30% | PEARLSBUCK | 10 | First American woman to win the Nobel Prize for Literature (3 wds.) |
| 30% | RETTON | 6 | First American woman to win all-around gymnastics gold at the Olympics |
| 29% | RONDA | 5 | Rousey, first American woman to win an Olympic medal in judo |
| 29% | DARNELL | 7 | ___ Martin, first African American woman to produce a film for a major studio (1994) |
| 29% | JANEADDAMS | 10 | First American woman to be awarded the Nobel Peace Prize, in 1931: 2 wds. |
| 29% | FRANCESARNOLD | 13 | First American woman to win the Nobel Prize in Chemistry, in 2018: 2 wds. |
| 29% | PEARLSBUCK | 10 | First American woman to win the Nobel Prize in Literature, in 1938: 3 wds. |
| 29% | ABBOTT | 6 | Margaret ___, golfer and the first American woman to win an Olympic event |
| 29% | BLACKWELL | 9 | Elizabeth __, first woman in US to become a doctor |
| 29% | RONDA | 5 | Rousey who was the first American woman to win an Olympic judo medal |
| 28% | JANEADDAMS | 10 | Social worker who was the first American woman to win the Nobel Peace Prize |
| 27% | MARIE | 5 | ___ Maynard Daly, the first African American woman to earn a Ph.D. in chemistry |
| 27% | KATHRYNBIGELOW | 14 | First woman to win a Best Director Oscar |
| 27% | SALLY | 5 | ___ Ride, American astronaut who became the first American woman to fly in space in 1983 |
| 27% | EDITS | 5 | Makes changes to a first draft |
| 27% | ITO | 3 | First woman to land a triple axel in competition |
| 27% | NORMA | 5 | Woman's name that becomes a man's name when its first letter is added to the end |
| 27% | HAIRRAISINGMOMENT | 17 | In developing her unique line of beauty products, Madam C.J. Walker had to fight through many a... |
| 27% | WILMA | 5 | Considered the world's fastest woman in the 60s, she became the first American woman to win three golds in a single Olympic Games |
| 27% | AWKWAFINA | 9 | First Asian-American woman to win a Golden Globe for lead actress in a film |
| 26% | LINDSEY | 7 | ___ Vonn, former alpine ski racer who was the first American woman to win an Olympic gold in downhill skiing |