| 100% | EILEEN | 6 | ___ Collins, American astronaut who became the first woman to command a space shuttle mission in 1999 |
| 65% | WHITSON | 7 | Peggy ___, American astronaut who became the first woman to command the International Space Station in 2007 |
| 56% | SALLY | 5 | ___ Ride, American astronaut who became the first American woman to fly in space in 1983 |
| 56% | KALPANA | 7 | ___ Chawla, American astronaut who became the first Indian woman to fly in space in 1997 |
| 56% | MAE | 3 | ___ Jemison, American astronaut who became the first African-American woman to travel to space in 1992 |
| 47% | EILEEN | 6 | ___ Collins, first woman to command a space shuttle |
| 46% | VALENTINA | 9 | ___ Tereshkova, cosmonaut who became the first woman to fly in space in 1964 |
| 44% | COLLINS | 7 | Eileen, first woman to command a space shuttle |
| 41% | RIDE | 4 | Astronaut Sally who was the first American woman in space |
| 38% | MAE | 3 | Astronaut Jemison who was the first African-American woman in space |
| 38% | EILEEN | 6 | Collins who was the first woman Space Shuttle commander |
| 38% | RIDE | 4 | She became the first American woman in space in 1983 |
| 38% | DANICAPATRICK | 13 | Racing great who became the first woman driver to win an Indy car race in April 2008 (2 wds.) |
| 38% | REBA | 4 | McEntire who is the first woman to portray Colonel Sanders in a KFC ad |
| 38% | ITO | 3 | Olympic skater who was the first woman to land a triple axel in competition |
| 38% | ITO | 3 | Skater Midori who was the first woman to land a triple axel in competition |
| 37% | ITO | 3 | In 1981, she became the first woman to land a triple-triple jump combination in competition |
| 37% | RUDOLPH | 7 | Wilma ___, late American sprinter who was the first American woman to win three gold medals in a single Olympic Games |
| 36% | ALAN | 4 | Astronaut Shepard who was the first American in space |
| 36% | MAE | 3 | Astronaut Jemison who was the first Black woman in space |
| 36% | OCHOA | 5 | Astronaut Ellen who was the first Hispanic woman in space |
| 36% | GIBB | 4 | Bobbi, who in 1966 became the first woman to run the entire Boston Marathon |
| 36% | GINNI | 5 | She is an American business leader who became the first woman to head tech giant IBM |
| 36% | STEVIENICKS | 11 | American singer and songwriter who became the first woman to be inducted twice into the Rock and Roll Hall of Fame: 2 wds. |
| 35% | SALLY | 5 | ___ Ride who was the first American woman in space |
| 35% | BARBARA | 7 | ___ A. Williams, American radio astronomer who was the first African-American woman to gain a PhD in Astronomy |
| 35% | BLACKWELL | 9 | Elizabeth ___, British physician who was the first woman to earn a medical degree in the US |
| 34% | ONEIL | 5 | Buck who became the first African American coach in the MLB |
| 34% | LEE | 3 | Rebecca ___ Crumpler, physician who was the first African-American woman in the US to earn a medical degree |
| 34% | ABLE | 4 | Monkey who became the first to return to Earth successfully in 1959 |