| 100% | NANCY | 5 | ___ Drew, mystery series protagonist created by Carolyn Keene |
| 40% | POKERFACE | 9 | Natasha Lyonne murder mystery series on Peacock created by 39-Across: 2 wds. |
| 36% | NANCYDREW | 9 | Sleuthing young woman penned by Carolyn Keene |
| 33% | KEENE | 5 | Carolyn __ (Nancy Drew series byline) |
| 33% | KEENE | 5 | Carolyn ___ (Nancy Drew series pen name) |
| 32% | KEENE | 5 | Carolyn ___ (pseudonym used by Nancy Drew ghostwriters) |
| 31% | ONE | 3 | "___ for the Money" (first in a mystery series by Janet Evanovich) |
| 30% | ARMANDGAMACHE | 13 | Québec Chief Inspector in the mystery series by 40-Across (2 wds.) |
| 30% | AUNT | 4 | "___ Dimity's Death" (first volume in a mystery series by Nancy Atherton) |
| 30% | WILLIAMMONK | 11 | Victorian inspector in a mystery series by novelist Anne Perry (2 wds.) |
| 30% | ROBERTLANGDON | 13 | Protagonist of the thriller series written by 18a: 2 wds. |
| 30% | ENOLA | 5 | "The ___ Holmes Mysteries" (book series by Nancy Springer) |
| 30% | ELENASTANDISH | 13 | Photographer in a post-WWI mystery series by novelist Anne Perry (2 wds.) |
| 30% | JOHNREBUS | 9 | Protagonist of the detective novel series by Ian Rankin: 2 wds. |
| 30% | NANCYDREW | 9 | Fictional girl detective who first appeared in 1930 novel The Secret of the Old Clock by Carolyn Keene |
| 29% | HAVEIEVER | 9 | Comedy series created by Mindy Kaling, Never __ |
| 29% | MORTICIA | 8 | ___ Addams, matriarch played by Carolyn Jones in the 1964 TV series "The Addams Family" |
| 29% | THEPITTFAMILY | 13 | Household of Victorian investigators in a mystery series by novelist Anne Perry (3 wds.) |
| 29% | VAAN | 4 | Fictional sky pirate created by Yasumi Matsuno and seen in the "Final Fantasy" series |
| 29% | FAERIE | 6 | “___ Tale Theatre” (TV series created and hosted by Shelley Duvall) |
| 29% | STARTREK | 8 | TV series created by Gene Roddenberry, with Spock |
| 29% | GIRLS | 5 | HBO series created by and starring Lena Dunham |
| 29% | ATLANTA | 7 | FX series created by and starring Donald Glover |
| 29% | KEENE | 5 | Carolyn who wrote Nancy Drew mysteries |
| 29% | GLASSHOUSES | 11 | Most recent novel in the mystery series by 40-Across featuring 30-Across (2 wds.) |
| 29% | LADIES | 6 | "The No. 1 ___ Detective Agency" (first novel in a mystery series by Alexander McCall Smith) |
| 28% | LILAC | 5 | "The Mystery at ___ Inn" (fourth book in the Nancy Drew series) |
| 27% | ARMANDGAMACHE | 13 | Chief inspector in a series of mystery novels by Louise Penny (2 wds.) |
| 27% | HERBS | 5 | The —, 1968 BBC TV children's series created and written by Michael Bond |
| 27% | FAMILYGUY | 9 | Fox animated series created by Seth MacFarlane: 2 wds. |