| 100% | PETER | 5 | ___ Griffin, popular television character voiced by Seth MacFarlane in the animated sitcom "Family Guy" |
| 65% | HOMER | 5 | Popular television character voiced by Dan Castellaneta in the animated sitcom "The Simpsons" |
| 44% | ROSS | 4 | ___ Geller, popular television character played by David Schwimmer in the sitcom "Friends" |
| 44% | BING | 4 | Chandler ___, popular television character played by Matthew Perry in the sitcom "Friends" |
| 44% | COSMO | 5 | ___ Kramer, popular television character played by Michael Richards in the sitcom "Seinfeld" |
| 44% | SCOTT | 5 | Michael ___, popular television character played by Steve Carell in the sitcom "The Office" |
| 43% | COOPER | 6 | Sheldon ___, popular television character played by Jim Parsons in the sitcom "The Big Bang Theory" |
| 42% | BELCHER | 7 | Bob ___, Chef in the 2011 animated television sitcom "Bob's Burgers," voiced by H. Jon Benjamin |
| 41% | DARIA | 5 | ___ Morgendorffer, iconic female character voiced by Tracy Grandstaff in the eponymous animated sitcom |
| 40% | STEWIE | 6 | Griffin family member voiced by Seth MacFarlane |
| 38% | KATARA | 6 | Iconic female character voiced by Mae Whitman in the animated show "Avatar: The Last Airbender" |
| 38% | DOC | 3 | Character voiced by Roy Atwell in 1937 animated film Snow White and the Seven Dwarfs |
| 38% | SNEEZY | 6 | Character voiced by Billy Gilbert in 1937 animated film Snow White and the Seven Dwarfs |
| 38% | KIM | 3 | ___ Possible, iconic female character voiced by Christy Carlson Romano in the eponymous animated show |
| 38% | TED | 3 | Movie character voiced by Seth MacFarlane |
| 37% | WALTER | 6 | ___ White, popular television character played by Bryan Cranston in the drama "Breaking Bad" |
| 37% | TED | 3 | Movie title character voiced by Seth MacFarlane |
| 37% | JETSONS | 7 | "The ___," animated sitcom produced by Hanna-Barbera which is about a family in the future |
| 37% | MEG | 3 | Character voiced by Mila Kunis in "Family Guy" |
| 37% | FAMILY | 6 | American animated sitcom "___ Guy" featuring the Griffins which is in its 16th season |
| 36% | SLEEPY | 6 | Somnolent character voiced by Pinto Colvig in 1937 animated film Snow White and the Seven Dwarfs |
| 36% | HELEN | 5 | ___ Parr, iconic female character voiced by Holly Hunter in the animated film "The Incredibles" |
| 36% | FLAME | 5 | ___ Princess, iconic female character voiced by Jessica DiCicco in the animated show "Adventure Time" |
| 36% | SETHMACFARLANE | 14 | Creator of the American animated sitcom "Family Guy" who also voices other characters of the show: 2 wds. |
| 36% | AMERICANDAD | 11 | Animated show in which the father (voiced by Seth MacFarlane) works for the CIA: 2 wds. |
| 36% | THESIMPSONS | 11 | Fox animated sitcom in which 17-Across voices the recurring character Fat Tony: 2 wds. |
| 36% | FUTURAMA | 8 | Popular animated sitcom created by Matt Groening about Earth in the year 3000 |
| 36% | BRIAN | 5 | "Family Guy" dog voiced by Seth MacFarlane |
| 35% | FAMILYGUY | 9 | Seth MacFarlane animated series featuring the voices of 15-Across, 26-Across, and 34-Across that debuted in 1999 (2 wds.) |
| 35% | GUY | 3 | "___ Guy," animated sitcom created by Seth MacFarlane |