| 100% | ENOLA | 5 | ___ Holmes (Sherlock’s sleuthing sibling) |
| 80% | ENOLA | 5 | — Holmes (Sherlock’s sleuthing sister) |
| 80% | ENOLA | 5 | ___ Holmes (Sherlock’s sleuthing sister) |
| 78% | ENOLA | 5 | ___ Holmes (Sherlock’s sleuthing younger sister) |
| 78% | ENOLA | 5 | — Holmes (Sherlock’s sleuthing younger sister) |
| 73% | ENOLA | 5 | ___ Holmes, Sherlock Holmes' sleuthing younger sister |
| 63% | ENOLAHOLMES | 11 | Sherlock’s sleuthing sister, in a 2020 film |
| 62% | SIGERSON | 8 | __ Holmes, Sherlock's Smarter Brother on film |
| 62% | JOHNWATSON | 10 | Sherlock Holmes's chronicler |
| 62% | MYCROFT | 7 | Sherlock Holmes's brother |
| 62% | WATSON | 6 | Sherlock Holmes's colleague |
| 61% | ADLER | 5 | Sherlock Holmes's love Irene ___ |
| 61% | WATSON | 6 | Sherlock Holmes's friend John |
| 61% | WATSON | 6 | Sherlock Holmes's best friend |
| 59% | JOHNWATSON | 10 | Sherlock Holmes's sidekick: 2 wds. |
| 59% | ENOLA | 5 | Sherlock Holmes's sister, on Netflix |
| 58% | AQUILINE | 8 | Like Sherlock Holmes's nose |
| 58% | AFOOT | 5 | Like Sherlock Holmes's "game" |
| 57% | DEERSTALKER | 11 | Part of Sherlock Holmes's attire |
| 56% | WATSON | 6 | Super sleuth Sherlock's sidekick |
| 55% | DOCTOR | 6 | With 41-Across, Sherlock Holmes's confidant |
| 55% | RITCHIE | 7 | 2009's steampunk Sherlock Holmes director: Guy __ |
| 55% | ENOLA | 5 | "___ Holmes" (film about Sherlock's sister) |
| 55% | ENOLA | 5 | — Holmes (Sherlock’s sister) |
| 55% | ENOLA | 5 | ___ Holmes (Sherlock's sister) |
| 54% | ADLER | 5 | Irene who's a frenemy of Sherlock Holmes |
| 54% | JUDELAW | 7 | Played Watson in Guy Ritchie's Sherlock Holmes |
| 54% | INSP | 4 | Lestrade's rank, in Sherlock Holmes stories: Abbr. |
| 53% | ENOLA | 5 | ___ Holmes (Sherlock's little sister) |
| 53% | ENOLA | 5 | Sherlock Holmes's younger sister in a series of YA novels |