| 100% | ONE | 3 | ___ hundred, the difference between 1922 and 2022 |
| 56% | ANO | 3 | The difference between Jan and Joan? |
| 56% | ANI | 3 | The difference between Mara and Maria? |
| 55% | BLURREDLINE | 11 | The difference between ethical and unethical, sometimes |
| 54% | ANE | 3 | The difference between regular mail and e-mail? |
| 54% | HEMLINE | 7 | The difference between a mini and a midi |
| 53% | ANS | 3 | The difference between what he said and what she said |
| 53% | TENSE | 5 | The difference between who I was and who I am? |
| 52% | INCOMEGAP | 9 | Difference between the rich and the poor |
| 50% | TENSE | 5 | What might be the difference between "read" and "read" |
| 48% | EPACT | 5 | Difference in days between the lunar and solar year |
| 48% | EDGE | 4 | It can be the difference between winning and losing |
| 47% | TENS | 4 | Column between the ones and hundreds columns |
| 47% | TENS | 4 | Math column between the ones and hundreds |
| 47% | TENS | 4 | Addition column between the ones and the hundreds |
| 45% | DESSERTEDUCATOR | 15 | Someone who teaches people the difference between flan and creme brulee? |
| 45% | PRACTICE | 8 | "The difference between ordinary and extraordinary," per Vladimir Horowitz |
| 43% | CONTRAST | 8 | Show the difference between |
| 42% | GAP | 3 | Generation ___ (difference between the young and the old) |
| 42% | CONTRAST | 8 | The difference between darks/lights in an image |
| 42% | COMPARINGKNIVES | 15 | Noting the differences between cutting utensils? |
| 41% | DEUCE | 5 | Difference between 19 and 21 |
| 41% | SPREAD | 6 | Difference between winners and losers? |
| 41% | CASE | 4 | Difference between oo and OO |
| 41% | TENSE | 5 | Difference between is and was |
| 41% | PEE | 3 | Difference between icky and picky? |
| 41% | TENSE | 5 | Difference between lead and led |
| 41% | TENSE | 5 | Difference between “put” and “put” |
| 41% | SPREAD | 6 | Difference between prices bid and asked |
| 41% | SECONDS | 7 | Difference between winning and losing, maybe |