| 100% | MARY | 4 | ___ Jackson, NASA's first African-American female engineer |
| 55% | KITTY | 5 | ___ O'Brien Joyner, NASA's first female engineer |
| 54% | ELISE | 5 | Educator/writer ___ Johnson McDougald, first African American female principal in New York City public schools |
| 54% | LEE | 3 | Rebecca ___ Crumpler, first African-American female physician in the U.S. |
| 52% | MAE | 3 | First African-American female astronaut Jemison |
| 51% | MAE | 3 | Astronaut Jemison, the first African-American woman in NASA's training program |
| 48% | SELMA | 5 | James Perkins Jr. was this Alabama city's first African American mayor |
| 47% | BRAGG | 5 | Alvin ___, first African American to be elected Manhattan's district attorney |
| 47% | RITA | 4 | Dove, who became the first African American U.S. Poet Laureate |
| 46% | LORETTA | 7 | ___ Lynch, first African American woman to serve as U.S. attorney general |
| 46% | MOMSMABLEY | 10 | Trailblazing African American who was the first female comedian to perform at the Apollo Theater: 2 wds. |
| 46% | ROBINSON | 8 | First African American MLB player, Jackie __ |
| 44% | JEMISON | 7 | Mae, first African American woman in space |
| 43% | ZAILAAVANTGARDE | 15 | First African American to win the Scripps National Spelling Bee |
| 43% | FAYETTEVILLE | 12 | Where Senator Hiram Rhodes Revels, first African American to serve in the U.S. Congress, was born |
| 42% | LLOYD | 5 | Earl ___, first African American to play in the NBA |
| 41% | ALTHEA | 6 | ___ Gibson, first African American to win a Grand Slam title |
| 41% | DOUGWILLIAMS | 12 | First African American quarterback to be named 44-Across, in 1988: 2 wds. |
| 41% | ONEIL | 5 | Buck who became the first African American coach in the MLB |
| 41% | ANDERSON | 8 | Singer Marian, the first African American to perform at the Met |
| 41% | TIGERWOODS | 10 | First African-American to win golf's Masters Tournament: 2 wds. |
| 40% | OBAMA | 5 | Barack ___, first African-American president of the U.S. |
| 40% | MISTYCOPELAND | 13 | First African-American prima ballerina for the American Ballet Theater: 2 wds. |
| 40% | BUCK | 4 | O'Neil who was the first African American coach in the MLB |
| 39% | AKA | 3 | First African-American sorority |
| 39% | POITIER | 7 | Sidney who was the first African American to win a Best Actor Oscar |
| 39% | XXXXXXXX | 8 | First African-American woman to hold the post of U.S. poet laureate |
| 39% | FIGURES | 7 | "Hidden ___," 2016 biographical drama film based on the lives of African-American female mathematicians who worked at NASA |
| 39% | TIANA | 5 | First African-American Disney princess |
| 39% | DARNELL | 7 | ___ Martin, first African American woman to produce a film for a major studio (1994) |