| 100% | IMELDA | 6 | ___ Marcos, longtime first lady of the Philippines with a notorious shoe collection |
| 56% | IMELDA | 6 | ___ Marcos, longtime first lady of the Philippines |
| 42% | IMELDAMARCOS | 12 | First Lady of the Philippines from 1965-86 |
| 37% | NANCYREAGAN | 11 | First Lady of the United States (1981-1989) who wrote "To Love a Child": 2 wds. |
| 35% | URANUS | 6 | First planet discovered with the aid of a telescope |
| 34% | RAISA | 5 | First lady of the 1980s |
| 34% | EDITH | 5 | First lady of the 1910s |
| 34% | MAMIE | 5 | First lady of the 1950s |
| 34% | BARBARABUSH | 11 | First lady of the 1990s |
| 34% | NANCYREAGAN | 11 | First lady of the 1980s |
| 34% | EVAPERON | 8 | First lady of the 1940s-'50s |
| 34% | ZORRO | 5 | Swordsman associated with a mark shaped like the first letter of his name |
| 34% | ARGO | 4 | First steamship with a planned circumnavigation of the globe |
| 34% | EVAPERON | 8 | First lady of the 1940s and 1950s |
| 34% | EVAPERON | 8 | First Lady of the forties and fifties |
| 33% | RAISA | 5 | Last First Lady of the USSR |
| 33% | BILLIE | 6 | __ Holiday; First Lady of the Blues |
| 33% | SHARKWEEK | 9 | Discovery Channel summer programming event with a "Predator of the Deep" DVD collection (2 wds.) |
| 33% | HAYES | 5 | "First Lady of the American Theatre" Helen, for whom a Broadway theater is named |
| 33% | ALAI | 4 | Second word of a game name that rhymes with the first |
| 33% | MICHELLE | 8 | Obama, once First Lady of the USA |
| 33% | TODD | 4 | Mary ___ Lincoln, first lady of the 1860s |
| 33% | DONKEYKONG | 10 | Video game with a gorilla that first featured the main character of 43-Across (2 wds.) |
| 32% | JACKIEKENNEDY | 13 | First Lady who gave a 1962 TV tour of the White House after she oversaw its restoration: 2 wds. |
| 32% | RAISA | 5 | ___ Gorbachev, former first lady of the Soviet Union |
| 32% | AGUINALDO | 9 | First president of the Philippines: Emilio __ |
| 32% | RAISA | 5 | Last First Lady of the U.S.S.R. |
| 32% | DAVIDCUFIELD | 12 | First living magician with a star on the Hollywood Walk of Fame |
| 31% | IMELDA | 6 | Marcos of the Philippines |
| 31% | MICHELLEOBAMA | 13 | First Lady of the United States (2009-2017) who wrote "Becoming": 2 wds. |