| 100% | DONNA | 5 | ___ McKechnie, actress who played Debra, Sam's ex-wife on "Cheers" |
| 60% | SHELLEYLONG | 11 | "Cheers" actress who played Jay's ex-wife DeDe on "Modern Family": 2 wds. |
| 55% | CLAIREDANES | 11 | "Homeland" actress who plays Toby Fleishman's ex-wife on "Fleishman Is in Trouble" (2 wds.) |
| 54% | CHERYLHINES | 11 | Actress who plays the main character's ex-wife on "Curb Your Enthusiasm": 2 wds. |
| 53% | KATE | 4 | ___ Mulgrew, actress who played Janet Eldridge, Sam's love interest on "Cheers" |
| 53% | FELDON | 6 | Barbara ___, actress who played Lauren Hudson, Sam's love interest on "Cheers" |
| 53% | NOBLE | 5 | Chelsea ___, actress who played Laurie Marlowe, Sam's love interest on "Cheers" |
| 51% | POLLYBERGEN | 11 | "The Caretakers" actress who played Sam's wife Peggy in "Cape Fear": 2 wds. |
| 51% | CASSIDYFREEMAN | 14 | "Longmire" actress who plays Jesse's wife Amber on "The Righteous Gemstones": 2 wds. |
| 51% | GEORGIAENGEL | 12 | Actress who played anchorman Ted Baxter's wife on "The Mary Tyler Moore Show": 2 wds. |
| 51% | VALERIE | 7 | ___ Mahaffey, actress who played an eponymous character as Sam's love interest on "Cheers" |
| 50% | JILLHENNESSY | 12 | "Crossing Jordan" actress who plays Jackie's wife Jenny Rohr on "City on a Hill": 2 wds. |
| 50% | SIENNAMILLER | 12 | "Live by Night" actress who plays Roger's wife Beth Ailes on "The Loudest Voice" (2 wds.) |
| 49% | SUSIEESSMAN | 11 | Actress who plays the foul-mouthed wife of the main character's manager Jeff on "Curb Your Enthusiasm": 2 wds. |
| 49% | ARCHIEPANJABI | 13 | Actress who plays investigator Kalinda Sharma on "The Good Wife": 2 wds. |
| 49% | SAGAL | 5 | Actress Katey who plays Dan's wife on "The Conners" |
| 49% | KARLASOUZA | 10 | "How to Get Away With Murder" actress who plays ex-lawyer Marina on ABC's "Home Economics": 2 wds. |
| 48% | NAOMIWATTS | 10 | "King Kong" actress who plays wife Nora on 16-Across: 2 wds. |
| 47% | TERI | 4 | Actress Polo who played a presidential candidate's wife on "The West Wing" |
| 47% | SALLY | 5 | With 33-Across, actress who played Daniel's ex-wife Miranda in "Mrs. Doubtfire" |
| 46% | MOOREHEAD | 9 | Actress who played Endora on TV's "Bewitched" |
| 46% | HOPEDAVIS | 9 | "For the People" actress who plays mob wife Gina Baxter on 15-Across: 2 wds. |
| 46% | HOPEDAVIS | 9 | "Wayward Pines" actress who plays the wife of a mob boss on 54-Across (2 wds.) |
| 45% | DREW | 4 | Actress who played Sheila on Netflix's "Santa Clarita Diet" |
| 45% | TINALOUISE | 10 | Actress who played Ginger on "Gilligan's Island": 2 wds. |
| 45% | MJRODRIGUEZ | 11 | Actress who plays Blanca on FX's "Pose": 2 wds. |
| 45% | COURTENEYCOX | 12 | Actress who played a woman pretending to be Jerry's wife for a dry-cleaning discount on "Seinfeld," but is better known as Monica on "Friends" (2 wds.) |
| 45% | JUNESQUIBB | 10 | Actress who plays Woody's wife Kate in "Nebraska": 2 wds. |
| 45% | MOLLYRINGWALD | 13 | Actress who played Sam Baker in the 1984 film "Sixteen Candles" and Mary Andrews on "Riverdale" in 2019: 2 wds. |
| 45% | SUZANNESOMERS | 13 | Actress who played Chrissy Snow on "Three's Company" (2 wds.) |