| 100% | MARY | 4 | ___ Morstan, Watson's wife in the Sherlock Holmes stories who was played by Amanda Abbington on screen |
| 54% | IRENE | 5 | ___ Adler, iconic character from the Sherlock Holmes stories who was played by Lara Pulver on screen |
| 40% | PIKE | 4 | Langdale ___, gossipmonger in the Sherlock Holmes stories who is introduced in "The Adventure of the Three Gables" |
| 38% | ADLER | 5 | Irene who was played by Rachel McAdams in 2009’s “Sherlock Holmes” |
| 34% | ETHEL | 5 | Muggs who was played by Shannon Purser on The CW's "Riverdale" |
| 33% | ETTA | 4 | James who was played by Beyoncé in the biopic "Cadillac Records" |
| 32% | ANITA | 5 | Lawyer Hill who was played by Viola Davis in the HBO movie "Confirmation" |
| 32% | CULLEN | 6 | Fictional vampire Edward who is played by Robert Pattinson in the "Twilight" films |
| 32% | ENOLA | 5 | Holmes who was played by Millie Bobby Brown in 2020 and 2022 |
| 32% | DOCTORSTRANGE | 13 | Marvel superhero who was played by Benedict Cumberbatch in the titular 2016 film: 2 wds. |
| 32% | OYL | 3 | Olive who was played in "Popeye" by the late Shelley Duvall |
| 32% | COHN | 4 | Lawyer Roy who was played by Nathan Lane in the 2018 revival of “Angels in America” |
| 31% | JODIE | 5 | Actress Whittaker who will play the Doctor on "Doctor Who" in 2018 |
| 31% | DOLITTLE | 8 | John ___, fictional doctor played by Eddie Murphy in the 1998 film based on Hugh Lofting's stories |
| 31% | WILLFERRELL | 11 | "Anchorman" actor who plays Sherlock Holmes in the upcoming movie "Holmes & Watson": 2 wds. |
| 31% | MORSTAN | 7 | Mary __, Dr Watson's wife in the Sherlock tales |
| 30% | ELIOT | 5 | Prohibition agent Ness who was played by Kevin Costner in "The Untouchables" |
| 30% | FARKUS | 6 | Scut ___, villain in the 1983 film "A Christmas Story" who is played by Zack Ward |
| 30% | BRADBELLICK | 11 | Character played by Wade Williams who is introduced as the captain of Fox River's correctional officers in "Prison Break": 2 wds. |
| 29% | DALE | 4 | Character who was played by Jeffrey DeMunn on "The Walking Dead" |
| 29% | ALEC | 4 | Baldwin who was the first performer on screen in the current season of "Saturday Night Live" |
| 29% | STELLA | 6 | ___ Dallas, character played by Barbara Stanwyck who was mom to Laurel in the eponymous 1937 film |
| 29% | EZRA | 4 | Actor Miller who will play the Flash in 2017's "Justice League" |
| 29% | NITTI | 5 | Frank who was played by Stallone in "Capone" |
| 29% | MARTINFREEMAN | 13 | "The Hobbit" actor who plays Dr. Watson on the BBC's "Sherlock": 2 wds. |
| 29% | JUDELAW | 7 | Actor who plays John Watson in the 2009 film "Sherlock Holmes" (2 wds.) |
| 28% | LAERTES | 7 | Character in "Hamlet" who is struck by a poison-tipped sword (we did say the play's a tragedy) |
| 28% | DEDE | 4 | ___ Tate, character played by Jodie Foster who was mom to Fred in the 1991 film "Little Man Tate" |
| 28% | MORTY | 5 | ___ Seinfeld, Jerry's father who was played by two different actors on "Seinfeld" |
| 28% | IRENE | 5 | Adler of the Sherlock Holmes story “A Scandal in Bohemia” |