| 100% | NIA | 3 | ___ Nal, character from "Supergirl" who is the first transgender superhero on television |
| 47% | ISIS | 4 | Actress and activist King who was the first openly transgender competitor on “America’s Next Top Model” |
| 44% | KUDO | 4 | Jimmy ___, character from the manga series "Case Closed" who was based on Sherlock Holmes |
| 44% | HERLOCK | 7 | ___ Sholmes, character from the video game "Ace Attorney" who was based on Sherlock Holmes |
| 43% | MOANA | 5 | Character from the Disney Princess franchise who is chosen by the ocean in the film based on Polynesian mythology |
| 42% | BLACKLIGHTNING | 14 | Superhero dad who was the title character on a show on a 2018-2021 CW show: 2 wds. |
| 42% | NEIL | 4 | Armstrong who was the first person on the moon |
| 42% | ANAND | 5 | Viswanathan who was the first chess grandmaster from India |
| 42% | SANTOS | 6 | George who was the first Republican expelled from Congress |
| 42% | FELIX | 5 | Cartoon feline who was one of the first images shown on television |
| 42% | LORENA | 6 | Ochoa who was the first #1-ranked golfer from Mexico |
| 42% | LORENA | 6 | Ochoa who was the first No. 1 ranked golfer from Mexico |
| 41% | STU | 3 | Rasmussen who was the first openly transgender mayor in the U.S. |
| 41% | PETER | 5 | ___ Dinklage, actor who was part of the television show "Threshold" and is one of the main characters on "Game of Thrones" |
| 41% | ETHEL | 5 | Waters who was the first Black American to host a national television show |
| 41% | TYRA | 4 | Banks who was the first African-American woman on the cover of GQ |
| 41% | CLINTON | 7 | Hillary ___, politician and icon who was the first female senator from New York |
| 41% | SCOTT | 5 | Michael ___, entrepreneur who was the first CEO of Apple from 1977 to 1981 |
| 40% | TYRA | 4 | Banks who was the first African-American woman featured on the cover of "GQ" |
| 40% | NAOMAMPBELL | 11 | *Woman who was the first Black model to appear on the cover of Time |
| 40% | OMAR | 4 | Ilhan who was the first person to wear a hijab on the House floor |
| 40% | ANNE | 4 | Bradstreet who was the first published writer from England's North American colonies (1650) |
| 40% | ANDREAMCARDLE | 13 | Tony-nominated actress who was the first to play 40-Across on Broadway (2 wds.) |
| 39% | ALEC | 4 | Baldwin who was the first performer on screen in the current season of "Saturday Night Live" |
| 39% | ELAYNE | 6 | Boosler who was the first woman to have an hour-long comedy special on cable TV |
| 39% | BARRY | 5 | ___ Nelson, American actor who was the first to portray James Bond in a television series titled "Climax!" |
| 39% | RETTON | 6 | Gymnast Mary Lou who was the first woman to appear on the front of a Wheaties box |
| 39% | GERE | 4 | Richard who was the first man featured on the cover of American Vogue |
| 38% | NYAD | 4 | Diana who was the first person to swim from Cuba to Florida without the aid of shark protection (2013) |
| 38% | MURRAY | 6 | Bill ___, "Kingpin" actor and comedian who was the first guest on the "Late Show with David Letterman" in 1993 |