| 100% | BARRY | 5 | ___ Nelson, American actor who was the first to portray James Bond in a television series titled "Climax!" |
| 43% | LORRE | 5 | Peter who was the first actor to play a Bond villain |
| 43% | ETHEL | 5 | Waters who was the first Black American to host a national television show |
| 43% | POITIER | 7 | Sidney who was the first African American to win a Best Actor Oscar |
| 42% | REBA | 4 | McEntire who is the first woman to portray Colonel Sanders in a KFC ad |
| 40% | POITIER | 7 | Sidney who was the first African-American to win a Best Actor Oscar |
| 39% | WALKEN | 6 | Christopher ___, American actor who played the Bond villain in "A View to a Kill" |
| 39% | WILLIAMS | 8 | Robin ___, actor who was a stand-up comedian before rising to fame after playing Mork in the TV series "Mork & Mindy" |
| 39% | TYUS | 4 | Wyomia ___, former American sprinter who was the first person to retain the Olympic title in the 100 m |
| 39% | LEE | 3 | Rebecca ___ Crumpler, physician who was the first African-American woman in the US to earn a medical degree |
| 39% | DRURY | 5 | James —, actor who played the title role in US television Western series The Virginian |
| 38% | BASEHART | 8 | Richard —, actor who starred as Admiral Nelson in 1960s US television series Voyage to the Bottom of the Sea |
| 38% | RICHARD | 7 | & 4D Actor who starred as Admiral Nelson in 1960s US television series Voyage to the Bottom of the Sea |
| 38% | RUDOLPH | 7 | Wilma ___, late American sprinter who was the first American woman to win three gold medals in a single Olympic Games |
| 38% | REA | 3 | Actor Stephen who is portrayed as a character in the 2024 historical drama series “Say Nothing” |
| 38% | SEAN | 4 | Actor Connery who was the first James Bond |
| 38% | SUNILEE | 7 | Gymnast who was the first Hmong American athlete to compete in the Olympics |
| 37% | TOBEY | 5 | Actor Maguire who was the first to play Spider-Man in movies |
| 37% | LUKEAIKINS | 10 | American skydiver who was the first to land safely without a parachute or wingsuit from mid-tropospheric altitude: 2 wds. |
| 37% | DIAMONDJIMBRADY | 15 | Tycoon who was the first person in New York City to own a car |
| 37% | ITO | 3 | Olympic skater who was the first woman to land a triple axel in competition |
| 37% | ITO | 3 | Skater Midori who was the first woman to land a triple axel in competition |
| 37% | MOORE | 5 | Roger who was the oldest actor to play James Bond |
| 37% | CHRISTIAN | 9 | Film actor Bale, who was the first Non-American to portray Batman/ Bruce Wayne |
| 37% | JACOBY | 6 | Ellsbury who was the first Native American of Navajo descent to play in Major League Baseball |
| 37% | BLACKWELL | 9 | Elizabeth ___, British physician who was the first woman to earn a medical degree in the US |
| 36% | PARKER | 6 | Fess —, actor who played the title role in US television series Daniel Boone and Mr Smith Goes to Washington |
| 36% | MARLINS | 7 | Florida squad that was the first to win two World Series titles as a wild-card team |
| 36% | RYUN | 4 | Jim ___, athlete who was the first high school junior to run a mile in under four minutes |
| 36% | TONYSHALHOUB | 12 | Actor who played the title role in US television series Monk |