| 100% | REGIS | 5 | ___ Philbin, TV presenter and host who was the most frequent guest on the "Late Show with David Letterman" with 150 appearances |
| 53% | HANNA | 5 | Jack ___, zookeeper who was the second-most frequent guest on the "Late Show with David Letterman" with 103 appearances |
| 47% | MURRAY | 6 | Bill ___, "Kingpin" actor and comedian who was the first guest on the "Late Show with David Letterman" in 1993 |
| 44% | JOEL | 4 | Billy ___, "Uptown Girl" singer who was the first musical act on the "Late Show with David Letterman" in 1993 |
| 42% | REGIS | 5 | ___ Philbin, TV presenter and host who made a guest appearance as the voice of Mabel in the "Shrek" franchise |
| 37% | ROSIEODONNELL | 13 | American TV presenter and activist who has hosted several daytime television talk shows and was a moderator on "The View": 2 wds. |
| 37% | JOAN | 4 | ___ Rivers, comedian and actress who was the first woman to host a late-night network TV talk show |
| 36% | DARLENE | 7 | ___ Love, singer who annually performed the song "Christmas (Baby Please Come Home)" on the "Late Show with David Letterman" |
| 34% | COLBERT | 7 | Stephen ___, comedian who was the successor to David Letterman on the "Late Show" |
| 33% | MILEY | 5 | With 32-Across, "Party in the U.S.A." singer who was both the host and musical guest on 2013 and 2015 "SNL" episodes |
| 32% | HAMEL | 5 | Actress Veronica who was the model in the last cigarette ad shown on U.S. TV |
| 32% | BRIANWILLIAMS | 13 | American journalist who is the chief anchor on MSNBC and host of "The 11th Hour with ___": 2 wds. |
| 31% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 30% | HAMEL | 5 | Actress Veronica who was the model in the last cigarette ad ever shown on U.S. TV (Dec. 31, 1970) |
| 30% | BRITNEYSPEARS | 13 | "Slumber Party" singer who is the youngest person to be both host and musical guest on "Saturday Night Live" (2 wds.) |
| 29% | ARIANAGRANDE | 12 | "7 Rings" singer who was both the host and musical guest on a 2016 "SNL" episode: 2 wds. |
| 29% | HOME | 4 | "America's Funniest ___ Videos," video clip show that is based on the Japanese variety show "Fun TV with Kato-chan and Ken-chan" |
| 29% | VICTORIAARLEN | 13 | ESPN host and Paralympic swimmer who was a semifinalist on season 25 of "Dancing with the Stars" (2 wds.) |
| 29% | STEVE | 5 | ___ Jones, TV presenter who was a host on "The X Factor" |
| 29% | TOBY | 4 | Country singer Keith who appeared on the finales of "The Late Late Show With Craig Ferguson" and "The Colbert Report" |
| 29% | BILLIEEILISH | 12 | "Bad Guy" singer who was both the host and musical guest on a 2021 "Saturday Night Live" episode: 2 wds. |
| 29% | STEPHENCOLBERT | 14 | Host of "The Late Show" who was once a correspondent on "The Daily Show": 2 wds. |
| 28% | CRISTIANO | 9 | ___ Ronaldo, Portuguese soccer player who is the most followed athlete on Instagram with over 238 million followers |
| 28% | WOLFGANGPUCK | 12 | Austrian-born American chef, who owns the restaurant "Spago", and has appeared as a guest judge on many reality shows: 2 wds. |
| 28% | LENO | 4 | Host who guested on Craig Ferguson’s final “Late Late Show” |
| 28% | STEPHENCOLBERT | 14 | American late night show host who wrote the book "I Am America (And So Can You!)": 2 wds. |
| 28% | NOEL | 4 | ___ Fielding, comedian and frequent guest on the British TV series "Never Mind the Buzzcocks" |
| 28% | SNL | 3 | Show whose most frequent guest host has been Alec Baldwin (17 times): Abbr. |
| 27% | JAMESCORDEN | 11 | English late night show host who was the co-creator of BBC's Gavin & Stacey: 2 wds. |
| 27% | DIANE | 5 | ___ Chambers, character on the TV show "Cheers" who was played by Shelley Long |