| 100% | EMELIA | 6 | ___ Ricoletti aka "The Abominable Bride," Holmes' nemesis portrayed by Natasha O'Keeffe on BBC's "Sherlock" |
| 44% | HOPE | 4 | Jeff ___, Holmes' nemesis portrayed by Phil Davis on BBC's "Sherlock" |
| 44% | JIM | 3 | ___ Moriarty, Holmes' nemesis portrayed by Andrew Scott on BBC's "Sherlock" |
| 43% | CHARLES | 7 | ___ Augustus Magnussen, Holmes' nemesis portrayed by Lars Mikkelsen on BBC's "Sherlock" |
| 31% | MARY | 4 | ___ Morstan, Watson's wife in the Sherlock Holmes stories who was played by Amanda Abbington on screen |
| 30% | JOHNNOBLE | 9 | The actor who portrays Morland Holmes, the father of Sherlock Holmes on "Elementary": 2 wds. |
| 28% | IRENE | 5 | ___ Adler, iconic character from the Sherlock Holmes stories who was played by Lara Pulver on screen |
| 27% | LEEMILLER | 9 | Jonny ___ - whose birthday it is today - the actor who portrays Sherlock Holmes on the hit TV series "Elementary": 2 wds. |
| 26% | BEN | 3 | Nickname for actor Cumberbatch who portrayed Sherlock Holmes in the BBC series "Sherlock" |
| 25% | DATA | 4 | Android portrayed by Brent Spiner on "Star Trek: The Next Generation" |
| 25% | MASON | 5 | Perry ___, famous TV lawyer portrayed by Raymond Burr on the eponymous show |
| 25% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 25% | ALLY | 4 | ___ McBeal, famous TV lawyer portrayed by Calista Flockhart on the eponymous TV show |
| 25% | TRIPODS | 7 | The —, 1980s BBC TV series based on novels by John Christopher |
| 25% | CALABASH | 8 | Type of pipe smoked by Sherlock Holmes on screen |
| 24% | FOUR | 4 | "The Sign of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 24% | BASKERVILLES | 12 | "The Hound of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 24% | IDO | 3 | Words exchanged by the bride and groom on their wedding day |
| 24% | IRENE | 5 | Adler portrayed by Lara Pulver on "Sherlock" |
| 23% | DOYLE | 5 | Writer pressured by fans to bring Sherlock Holmes back from the dead |
| 23% | CESARE | 6 | Borgia portrayed by François Arnaud on "The Borgias" |
| 23% | ENOLA | 5 | Sherlock Holmes's sister, on Netflix |
| 23% | JANE | 4 | Patrick ___, protagonist of the drama "The Mentalist" who was based on Sherlock Holmes |
| 23% | KOREYWISE | 9 | Exonerated suspect portrayed by 33-Across in the miniseries "When They See Us" on 19-Across: 2 wds. |
| 23% | KUDO | 4 | Jimmy ___, character from the manga series "Case Closed" who was based on Sherlock Holmes |
| 23% | HERLOCK | 7 | ___ Sholmes, character from the video game "Ace Attorney" who was based on Sherlock Holmes |
| 23% | ELNINO | 6 | Weather phenomenon portrayed by Chris Farley on "S.N.L." |
| 22% | SIGERSON | 8 | __ Holmes, Sherlock's Smarter Brother on film |
| 22% | MARKETPRICE | 11 | On menus, it's often by the lobster |
| 22% | ALITO | 5 | O'Connor's successor on the Supreme Court |