| 100% | RICHARD | 7 | ___ Rodgers, composer with works like "Oklahoma!' and "The Sound of Music" who was the first person to win the EGOT |
| 47% | HAYES | 5 | Actress Helen who was the first person to win the Triple Crown of Acting |
| 47% | CURIE | 5 | Last name of the first woman to win the Nobel Prize and who is credited with the theory of radioactivity |
| 43% | ALTHEA | 6 | Gibson who was the first person of color to win a tennis Grand Slam event |
| 43% | ALTHEAGIBSON | 12 | Tennis great who was the first person of color to win a Wimbledon championship (2 wds.) |
| 42% | STEVENASH | 9 | Basketball Hall of Famer who was the first Canadian to win the NBA MVP award |
| 42% | MARIE | 5 | Curie who was the first person to win two Nobel Prizes |
| 41% | TIMRICE | 7 | English lyricist and author with works like "Evita" and "Aladdin" who has won the EGOT: 2 wds. |
| 41% | LUISE | 5 | Rainer who was the first person to win two Academy Awards for acting |
| 41% | EDITHWHARTON | 12 | 13-Across and 25-Across writer who was the first woman to win a Pulitzer Prize in Literature, for her 1920 novel "The Age of Innocence" (2 wds.) |
| 41% | IVANI | 5 | Person who built the first stone Cathedral of the Archangel in Moscow and was also the first person to be buried there |
| 40% | MUHAMMADYUNUS | 13 | Social entrepreneur and economist who was the first Bangladeshi to win the Nobel Peace Prize: 2 wds. |
| 39% | SIDNEYPOITIER | 13 | 15-Across, 30-Across, and "Lilies of the Field" star who was the first Black man to win an Academy Award for Best Actor (2 wds.) |
| 39% | SARAZEN | 7 | Gene who was the first man to win all four of golf’s modern majors |
| 39% | KAMALAHARRIS | 12 | Former California senator who is the first woman and first person of color to be inaugurated as vice president of the United States (2 wds.) |
| 39% | YURIGAGARIN | 11 | Russian who was the first person to travel into space and orbit the earth (1961): 2 wds. |
| 38% | AUDREYHEPBURN | 13 | British actress from "Sabrina" who is one of the 12 people to have won the EGOT: 2 wds. |
| 38% | JOCELYNALO | 10 | Softball player who won two championships with the University of Oklahoma and who is both the NCAA's all-time home run leader and the only player to record three 30-home run seasons (2 wds.) |
| 38% | NYAD | 4 | Diana who was the first person to swim from Cuba to Florida without the aid of shark protection (2013) |
| 38% | VOICE | 5 | With 64-Across, performer who is like the words sounded out at the starts of the answers to the four starred clues |
| 38% | ROBERTFROST | 11 | 17-Across and 26-Across writer who is the only person to win four Pulitzer Prizes for Poetry (2 wds.) |
| 38% | RITAMORENO | 10 | Puerto Rican actress from "West Side Story" who is one of the 12 people to have won the EGOT: 2 wds. |
| 37% | SHERYLSWOOPES | 13 | Basketball Hall of Fame inductee who was the first player to sign with the WNBA: 2 wds. |
| 37% | JOHNWILLIAMS | 12 | Composer who has worked with Spielberg on many films like "E.T. the Extra-Terrestrial," and is also the composer for 33a: 2 wds. |
| 37% | CAROLEKING | 10 | "You've Got a Friend" singer/pianist who was the first woman to win a Grammy for Song of the Year (2 wds.) |
| 37% | HAYES | 5 | Helen who was the first actress to achieve the EGOT |
| 37% | MARTINBRODEUR | 13 | Former New Jersey Devils' goaltender who has the highest number of wins with 691 wins and was elected to the Hockey Hall of Fame in 2018: 2 wds. |
| 37% | YUTOHORIGOME | 12 | Japanese skateboarder who was the first person to win a gold medal in skateboarding at the Olympics, in men's street skateboarding in Tokyo in 2021 (2 wds.) |
| 37% | VIOLA | 5 | Actress Davis who was the first African American to win the Triple Crown of Acting |
| 37% | SAMSMITH | 8 | "Stay With Me" singer who was a first-time Grammy nominee for Record of the Year (and won): 2 wds. |