| 100% | URSULA | 6 | ___ von der Leyen, first female head of the European Commission, who negotiated Brexit for the E.U. |
| 34% | LAGARDE | 7 | Christine, first female head of the IMF |
| 31% | PELOSI | 6 | Congresswoman Nancy who was the first female Speaker of the House |
| 31% | ASTOR | 5 | Nancy who served as the first female member of the British Parliament |
| 30% | INDIRA | 6 | Gandhi who was the first female PM of India |
| 30% | DOS | 3 | Heading for the first of two columns |
| 30% | NANCYPELOSI | 11 | Democratic congresswoman from California who was the first female Speaker of the House: 2 wds. |
| 30% | KAMALA | 6 | First name of the first female US vice president |
| 30% | HARRIS | 6 | The first female vice president-elect of the US |
| 29% | NEHRU | 5 | His sister, Vijaya Lakshmi Pandit, was the first female president of the U.N. General Assembly |
| 29% | ARTHURASHE | 10 | Winner of the first US Open Men's Singles championship (1968), for whom the largest stadium at the USTA National Tennis Center is named (2 wds.) |
| 29% | CANDICEBERGEN | 13 | Actress who was the first female host of "Saturday Night Live": 2 wds. |
| 29% | EARHART | 7 | First president of the Ninety-Nines, an organization for female pilots |
| 29% | RENO | 4 | Janet who was the first female US attorney general |
| 29% | RUTHELIZABETH | 13 | "Jezebel" actress ___ "Bette" Davis who became the first female recipient of the AFI Life Achievement Award: 2 wds. |
| 29% | LARAINENEWMAN | 13 | Female member of the first "Saturday Night Live" cast, known for playing Connie Conehead: 2 wds. |
| 29% | MARIECURIE | 10 | Scientist who was the first female professor at the University of Paris: 2 wds. |
| 29% | NAOMI | 5 | Girma who was the U.S. Soccer Female Player of the Year in 2023 |
| 29% | MIA | 3 | Hamm who was named U.S. Soccer Female Player of the Year five times |
| 29% | DEB | 3 | Haaland who facilitated the first apology by a U.S. President for forced assimilation of Indigenous children at government boarding schools (October, 2024) |
| 29% | JODIE | 5 | ___ Whittaker, player of the first female Doctor on "Doctor Who" |
| 28% | CANDICEBERGEN | 13 | "Murphy Brown" star who was the first female host of "Saturday Night Live": 2 wds. |
| 28% | RENO | 4 | Janet who was the U.S.’s first female Attorney General |
| 28% | RICE | 4 | Condoleezza who was the first female African-American secretary of state |
| 28% | HRC | 3 | Inits. of the first female presidential candidate for a major party |
| 28% | JOHNSON | 7 | He was US president for the first 20 days of 1969 |
| 28% | MAMA | 4 | Female head of the family |
| 28% | MUTTER | 6 | Carol, first female three star general of the US Marine Corps (1996) |
| 28% | PELOSI | 6 | First female speaker of the House |
| 28% | RONDA | 5 | ___ Rousey, first female fighter inducted into the U.F.C. Hall of Fame |