| 100% | STA | 3 | ___r Trek is a began as a Sci-fi TV series in 1966 |
| 48% | EXPANSE | 7 | "The ___," sci-fi TV series starring Steven Strait that is set in a future where humans colonize the Solar System |
| 47% | SILO | 4 | Sci-fi TV series starring Rashida Jones that is set in a dystopian future where people exist only in a grain-storing tower |
| 43% | ADVENTURES | 10 | "The ___ of Pete & Pete," a TV series in which Steve Buscemi - whose birthday it is today - guest starred as Phil Hickle |
| 43% | BOYS | 4 | "The ___," satirical superhero TV series where Will Ferrell makes a brief cameo as himself in Season 4 |
| 43% | LIMITS | 6 | "The Outer ___" (1960s sci-fi TV series with a reboot in the 1990s) |
| 43% | DEADMANSWALK | 12 | Novel in 32-Across's "Lonesome Dove" adventure series that was adapted as a TV miniseries (3 wds.) |
| 43% | CARBON | 6 | "Altered ___," cyberpunk sci-fi TV series starring Chris Conner that is set in 2384 |
| 43% | ATLANTIS | 8 | "Stargate ___," sci-fi TV series that is a spin-off of "Stargate SG-1" |
| 41% | JVN | 3 | TV personality who is a grooming expert in the 2018 TV series, "Queer Eye," familiarly |
| 41% | GALACTICA | 9 | Dystopian sci-fi TV series "Battlestar ___" by Glen A. Larson, where humans are forced to abandon their planet |
| 41% | STAR | 4 | "___ Trek: The Next Generation," sci-fi series in which Stephen Hawking made a guest appearance |
| 40% | TAN | 3 | ___ France, TV personality who is a fashion expert in the 2018 TV series, "Queer Eye" |
| 40% | CARSON | 6 | ___ Kressley, TV personality who was a fashion expert in the 2003 TV series, "Queer Eye" |
| 39% | LIFEONMARS | 10 | 2008-2009 ABC sci-fi crime drama series that was a remake of a British TV series: 3 wds. |
| 39% | STARTREK | 8 | Spock is a main character in this TV series |
| 38% | WESTWORLD | 9 | Sci-fi TV series about a resort with robots |
| 38% | TEK | 3 | Drug in a sci-fi novel series |
| 38% | ALTEREDCARBON | 13 | American dystopian sci-fi TV series starring Joel Kinnaman which is based on a novel of the same name by Richard K. Morgan: 2 wds. |
| 38% | FANDOMS | 7 | Subcultures composed of people who are huge supporters and lovers of a certain thing, such as a movie or TV series |
| 37% | THEBEDFORD | 10 | "___ Diaries," a short-lived TV series in which Penn Badgley - whose birthday it is today - starred alongside Matthew Modine |
| 37% | APE | 3 | Dr. Cornelius, in a sci-fi film series |
| 37% | NEO | 3 | "The One," in a sci-fi film series |
| 37% | LALAW | 5 | TV series whose name is shown on a vanity license plate in its opening sequence |
| 37% | GALACTICA | 9 | Titular ship in a sci-fi series |
| 37% | GAME | 4 | "___ of Thrones," TV series that will begin taking the world by storm in 2011 |
| 36% | METYOURMOTHER | 13 | "How I ___," a popular TV series in which John Lithgow appeared as the father of Barney Stinson: 3 wds. |
| 36% | SUPERGIRL | 9 | TV series that stars Melissa Benoist as a comic book heroine whose secret identity is Kara Danvers |
| 36% | DEVIOUSMAIDS | 12 | Lifetime TV series starring 39-Across as a house cleaner in Beverly Hills (2 wds.) |
| 36% | TEDALLEN | 8 | TV personality who was a food and wine expert in the 2003 TV series, "Queer Eye": 2 wds. |