| 100% | VALLEY | 6 | __ of Fear, the last of the Sherlock Holmes novels |
| 68% | FOUR | 4 | "The Sign of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 68% | BASKERVILLES | 12 | "The Hound of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 66% | POISOND | 7 | Cause of death in the Sherlock Holmes novel "The Sign of the Four" |
| 61% | HOUND | 5 | "The ___ of the Baskervilles," iconic Sherlock Holmes novel with seemingly supernatural elements |
| 58% | NIGEL | 5 | Bruce of the Sherlock Holmes films |
| 57% | MOHICANS | 8 | The Last of the __, a novel and a film |
| 57% | UNCAS | 5 | The last of the Mohicans, in Cooper's novel |
| 55% | IRENE | 5 | Adler of the Sherlock Holmes story “A Scandal in Bohemia” |
| 53% | UNCAS | 5 | Title character in the J F Cooper novel The Last of the Mohicans |
| 53% | UNCAS | 5 | Title character in 1826 J F Cooper novel The Last of the Mohicans |
| 53% | MOHICANS | 8 | Fenimore Cooper novel about the last of this tribe |
| 53% | MORIARTY | 8 | Sherlock Holmes' adversary, the Napoleon of Crime |
| 52% | JUDELAW | 7 | Costar of Robert Downey, Jr. in the Sherlock Holmes films: 2 wds. |
| 51% | JUDITHKRANTZ | 12 | Late author of the novels Princess Daisy and Scruples |
| 51% | IRENE | 5 | Adler who is the protagonist of the novel “Good Night, Mr. Holmes” |
| 51% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 51% | IDIAMIN | 7 | The Last King of Scotland, in the 1998 Foden novel |
| 50% | ASTUDYIN | 8 | & 16D First of four Sherlock Holmes novels by Arthur Conan Doyle, published in book form in 1888 |
| 50% | PERCENTSOLUTION | 15 | ← Sherlock Holmes novel, with "The" |
| 50% | ENOLA | 5 | Sherlock Holmes's younger sister in a series of YA novels |
| 50% | BASIL | 5 | First name of Sherlock Holmes actor from the 1940s |
| 50% | THEMANSION | 10 | 1959 novel by William Faulkner that is the last of the trilogy on the Snopes family: 2 wds. |
| 49% | ALLINGHAM | 9 | Margery —, author of detective novels Mystery Mile and The Case of the Late Pig |
| 49% | ECO | 3 | Umberto —, late author of novels The Name of the Rose and Foucault's Pendulum |
| 49% | BAND | 4 | "The Adventure of the Speckled ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 49% | BLUE | 4 | "The Adventure of the ___ Carbuncle," Sherlock Holmes story that is set around Christmas |
| 49% | SIR | 3 | ___ Arthur Conan Doyle (title for the creator of Sherlock Holmes) |
| 49% | FODEN | 5 | Giles —, author of 1998 novel The Last King of Scotland |
| 49% | BOWEN | 5 | Elizabeth —, author of novels The Last September and Eva Trout |