| 100% | WADE | 4 | — Wilson, whose alter ego is the title character in 2018’s “Deadpool 2” |
| 47% | RICHARDCASTLE | 13 | Writer who was the title character in a 2009-2016 crime series: 2 wds. |
| 46% | GLOB | 4 | Swamp monster whose alter ego is Joseph Timms and who first appeared in Marvel Comics' "The Incredible Hulk", vol. 2 #121 |
| 45% | DEPP | 4 | Actor who voiced the title character in 2018's "Sherlock Gnomes" |
| 43% | BLACKLIGHTNING | 14 | Superhero dad who was the title character on a show on a 2018-2021 CW show: 2 wds. |
| 43% | CAR | 3 | What the title character in Stephen King's "Christine" is |
| 40% | ORCA | 4 | What the title character in "Free Willy" was |
| 39% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 39% | STCHROMA | 8 | 2024 Tyler, the Creator hit whose title is his alter ego: 2 wds., abbr. |
| 39% | DIANEKEATON | 11 | "Annie Hall" actress who voiced the title character's mother in 18-Across: 2 wds. |
| 39% | SETH | 4 | MacFarlane who voices the title character in the upcoming "Ted 2" |
| 39% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |
| 39% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character in Netflix's "Ratched": 2 wds. |
| 38% | MAHERSHALAALI | 13 | Actor whose role in 2018's "Green Book" is the longest Best Supporting Actor-winning performance (screen time 1:06:38): 2 wds. |
| 38% | MICHAELCERA | 11 | "Arrested Development" actor who voices the title character in Netflix's "Scott Pilgrim Takes Off": 2 wds. |
| 38% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 37% | DANIELKALUUYA | 13 | Actor who plays Slim, one of the title characters on the run in 2019's "Queen & Slim": 2 wds. |
| 37% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 37% | FERDIASHAW | 10 | Young actor who plays the title character in the 2020 movie "Artemis Fowl": 2 wds. |
| 37% | PETERDINKLAGE | 13 | "Game of Thrones" actor who plays the title character in "The Toxic Avenger": 2 wds. |
| 37% | TORI | 4 | Character in "Victorious" whose name appears in the title |
| 37% | MIKEMYERS | 9 | "SNL" cast member (1989-1995) who voiced the title character in the "Shrek" movies: 2 wds. |
| 37% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 36% | RENEEZELLWEGER | 14 | Actress who returns to play the title character in "Bridget Jones: Mad About the Boy": 2 wds. |
| 36% | NORMADESMOND | 12 | Character portrayed by actress Patti LuPone in the musical "Sunset Boulevard" which was based on a 1950 film of the same title: 2 wds. |
| 36% | LANCEARMSTRONG | 14 | Seven-time American champion of the Tour de France who most recently won in 2005 ... but whose titles were revoked: 2 wds. |
| 36% | BATMAN | 6 | Comic book character whose alter ego is Bruce Wayne |
| 36% | SUPERMAN | 8 | Comic book character whose alter ego is Clark Kent |
| 36% | IRONMAN | 7 | Superhero whose alter ego is Tony Stark (2 wds.) |
| 36% | GODOT | 5 | Beckett title character who is not in the cast |