| 100% | ARS | 3 | “___ Amatoria” (three-book series by Ovid on love and seduction) |
| 45% | BOD | 3 | BBC TV animated series for children based on books by Michael and Joanne Cole |
| 44% | EMILSKODA | 9 | Psychiatrist and frequent expert witness played by 47-Across on three "Law & Order" series (2 wds.) |
| 42% | FIRE | 4 | "___ Power," ongoing comic book series by Robert Kirkman and Chris Samnee |
| 41% | ISPY | 4 | Best-selling children's book series by Walter Wick and Jean Marzollo |
| 38% | POPE | 4 | "Battle ___," independent superhero comic book series created by Robert Kirkman and Tony Moore |
| 38% | GEORGE | 6 | Curious ___, mischievous monkey with a knack for adventure from the book series by Margret and H.A. Rey |
| 37% | HAM | 3 | "Green Eggs and ___," TV series inspired by a Dr. Seuss book |
| 37% | HAM | 3 | "Green Eggs and ___," TV series based on a Dr. Seuss book |
| 35% | KID | 3 | "Diary of a Wimpy ___," book series and media franchise created by Jeff Kinney that follows a middle-schooler |
| 35% | BUPKIS | 6 | TV series created by and starring Pete Davidson that is based on his life |
| 35% | TWILIGHT | 8 | Vampire book series by Stephenie Meyer |
| 35% | TWILIGHT | 8 | Popular book series by Stephenie Meyer |
| 35% | BONE | 4 | Comic book series by Jeff Smith |
| 35% | TOPSY | 5 | Title twin sister in a series of children's books by Jean and Gareth Adamson |
| 34% | HUNGER | 6 | The __ Games, book series by Suzanne Collins |
| 34% | BEFORETRILOGY | 13 | Series of three romantic dramas written/directed by Richard Linklater and starring 18-Across and 44-Across (2 wds.) |
| 34% | EARTHSEA | 8 | Fantasy book series by Ursula K Le Guin |
| 34% | EVERYTHING | 10 | "The Theory of ___," book by Stephen Hawking based on a series of lectures given at Cambridge University |
| 34% | RINGOFBRIGHT | 12 | 1969 comedy-drama film starring Bill Travers and Virginia McKenna based on a book by Gavin Maxwell |
| 34% | HENRYANDRIBSY | 13 | One in a series of books by 46-Across about a boy and his dog: 3 wds. |
| 33% | LETME | 5 | "___ Love You," 2016 song by DJ Snake and Justin Bieber that featured on the Billboard Hot 100: 2 wds. |
| 33% | SIN | 3 | "___ City" (neo-noir comic book series by Frank Miller) |
| 33% | BORROWERS | 9 | Small characters in a book series by Mary Norton |
| 33% | WIMPY | 5 | "Diary of a ___ Kid," book series by Jeff Kinney |
| 33% | EARTHS | 6 | "Crisis on Infinite ___," comic book maxiseries published by DC Comics and which is set in a shared universe |
| 33% | THEULTIMATUM | 12 | Netflix dating series subtitled "Marry or Move On" hosted by 26-Across and his wife Vanessa (2 wds.) |
| 33% | ISPY | 4 | Book series with riddles by Jean Marzollo |
| 33% | HOLYGHOST | 9 | Book by John Sandford which was part of the "Virgil Flowers" novel series and became a NYT 2018 Bestseller: 2 wds. |