| 100% | EYRE | 4 | “The ___ Affair” (2001 novel set partly in the world of an 1847 novel) |
| 48% | EYRE | 4 | "The ___ Affair" (murder mystery set in the universe of a Brontë novel) |
| 43% | LEGEND | 6 | The __ of Zelda, game set in the world of Hyrule |
| 43% | JIMTHORPE | 9 | The Greatest Athlete of the 20th Century, according to an ABC Wide World of Sports poll in 2001: 2 wds. |
| 42% | ICLZZZZUS | 9 | Classic 1934 novel written in the form of an autobiography |
| 42% | BABBITT | 7 | Novel set in the fictional town of Zenith |
| 42% | MARSODYSSEY | 11 | NASA's unmanned mission to the Red Planet launched in 2001, named in honor of an Arthur C. Clarke novel |
| 41% | HADES | 5 | Antagonist (and namesake) of a 2019 Tony-winning musical set partly in the underworld |
| 40% | COCO | 4 | Pixar film partly set in the Land of the Dead |
| 40% | THEGOODFIGHT | 12 | CBS All Access series set in the world of a Chicago law firm: 3 wds. |
| 40% | AMAP | 4 | "You will find ___ of the world in an Atlas": 2 wds. |
| 40% | INC | 3 | 2001 animated movie set in the monster world, "Monsters, ___." |
| 39% | FAIREST | 7 | 2006 novel by Gail Carson Levin set in the kingdom of Ayortha |
| 39% | OMOO | 4 | 1847 novel subtitled "A Narrative of Adventures in the South Seas" |
| 39% | SCOTTTUROW | 10 | Author of novels set in the fictional Kindle County |
| 39% | PUDDNHEAD | 9 | & 21A 1894 novel by Mark Twain set in the town of Dawson's Landing |
| 38% | MUSEUM | 6 | Site of an art heist in The Thomas Crown Affair |
| 38% | MAD | 3 | "___ Men," sitcom set in the competitive world of 1960s advertising |
| 38% | GENOME | 6 | The full set of genes in an organism |
| 38% | NARNIA | 6 | Setting of seven fantasy novels by C S Lewis published in the 1950s |
| 38% | THEBURGESSBOYS | 14 | Elizabeth Strout novel set in the fictional town of Shirley Falls about two brothers (3 wds.) |
| 38% | EYE | 3 | In the twinkling of an ___ |
| 38% | EYE | 3 | In the blink of an ___ |
| 38% | LAKE | 4 | "In the ___ of the Woods" (Tim O'Brien novel set in northern Minnesota) |
| 38% | GISSING | 7 | George —, author of novels The Nether World and Workers in the Dawn |
| 38% | VERNE | 5 | Jules —, French author of 1873 novel Around the World in Eighty Days |
| 38% | JULES | 5 | & 4D French author of 1873 novel Around the World in Eighty Days |
| 37% | AMYDORRIT | 9 | Title character of an 1857 novel by Charles Dickens born and raised in the Marshalsea debtors' prison |