| 100% | HOUND | 5 | “The ___ of the Baskervilles” (Sherlock Holmes novel) |
| 100% | HOUND | 5 | "The ___ of the Baskervilles" (Sherlock Holmes novel) |
| 98% | HOUND | 5 | "The ___ of the Baskervilles," iconic Sherlock Holmes novel with seemingly supernatural elements |
| 78% | VALLEY | 6 | __ of Fear, the last of the Sherlock Holmes novels |
| 78% | POISOND | 7 | Cause of death in the Sherlock Holmes novel "The Sign of the Four" |
| 76% | FOUR | 4 | "The Sign of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 76% | BASKERVILLES | 12 | "The Hound of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 71% | COOK | 4 | Peter ___, actor who played Sherlock Holmes in the 1978 British film "The Hound of the Baskervilles" |
| 65% | MORIARTY | 8 | Sherlock Holmes' adversary, the Napoleon of Crime |
| 64% | NIGEL | 5 | Bruce of the Sherlock Holmes films |
| 63% | BAND | 4 | "The Adventure of the Speckled ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 63% | BLUE | 4 | "The Adventure of the ___ Carbuncle," Sherlock Holmes story that is set around Christmas |
| 63% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 62% | PERCENTSOLUTION | 15 | ← Sherlock Holmes novel, with "The" |
| 62% | ENOLA | 5 | Sherlock Holmes's younger sister in a series of YA novels |
| 62% | BASIL | 5 | First name of Sherlock Holmes actor from the 1940s |
| 61% | SIR | 3 | ___ Arthur Conan Doyle (title for the creator of Sherlock Holmes) |
| 61% | IRENE | 5 | Adler of the Sherlock Holmes story “A Scandal in Bohemia” |
| 59% | JUDELAW | 7 | Costar of Robert Downey, Jr. in the Sherlock Holmes films: 2 wds. |
| 59% | IRENE | 5 | Adler who is the protagonist of the novel “Good Night, Mr. Holmes” |
| 59% | ASTUDYIN | 8 | & 16D First of four Sherlock Holmes novels by Arthur Conan Doyle, published in book form in 1888 |
| 59% | JOHNNOBLE | 9 | The actor who portrays Morland Holmes, the father of Sherlock Holmes on "Elementary": 2 wds. |
| 58% | JANE | 4 | Patrick ___, protagonist of the drama "The Mentalist" who was based on Sherlock Holmes |
| 57% | COAT | 4 | Category of clothing that the Inverness Cape commonly associated with Sherlock Holmes belongs to |
| 57% | IRENE | 5 | Adler of the “Sherlock Holmes” stories |
| 57% | BELL | 4 | Joseph ___, surgeon whom Arthur Conan Doyle cites as inspiration for the character of Sherlock Holmes |
| 56% | POE | 3 | Edgar Allan ___, author who created the character of C. Auguste Dupin, a precursor to Sherlock Holmes |
| 55% | PIKE | 4 | Langdale ___, gossipmonger in the Sherlock Holmes stories who is introduced in "The Adventure of the Three Gables" |
| 55% | BRETT | 5 | Jeremy —, actor who played the title role in 1980s ITV drama series The Adventures of Sherlock Holmes |