| 100% | DOROTHYARZNER | 13 | “The Bride Wore Red” director who was the first woman to join the Directors Guild of America |
| 55% | DOMEE | 5 | Shi who was the first woman to have the sole director’s credit on a Pixar feature, for “Turning Red” |
| 50% | SAHLE | 5 | ___-Work Zewde, Ethiopian politician who is the first woman to serve as the President of Ethiopia |
| 50% | DEVI | 4 | Bidya ___ Bhandari, Nepalese politician who is the first woman to serve as the President of Nepal |
| 50% | RETTON | 6 | Gymnast Mary Lou who was the first woman to appear on the front of a Wheaties box |
| 49% | SHERYL | 6 | I wrote "Lean In" and became the first woman to join Facebook's board of directors |
| 49% | MIA | 3 | ___ Mottley, Barbadian politician who is the first woman to serve as the Prime Minister of Barbados |
| 46% | CAROLEKING | 10 | "You've Got a Friend" singer/pianist who was the first woman to win a Grammy for Song of the Year (2 wds.) |
| 46% | CURIE | 5 | Last name of the first woman to win the Nobel Prize and who is credited with the theory of radioactivity |
| 45% | ANNMEYERS | 9 | Basketball Hall-of-Famer who was the first woman to sign an N.B.A. contract |
| 45% | TINAFEY | 7 | Actress/writer who was the first woman to be head writer of "Saturday Night Live," and the third woman to host five times (2 wds.) |
| 45% | JEN | 3 | Cartoonist Sorensen who was the first woman to win the Herblock Prize |
| 45% | ZAHA | 4 | Hadid who was the first woman to win the Pritzker Architecture Prize |
| 45% | EDITH | 5 | Wharton who was the first woman to win the Pulitzer Prize for Literature |
| 45% | MARYAM | 6 | ___ Mirzakhani, an Iranian mathematician who was the first woman to receive the Fields Medal |
| 45% | HAYES | 5 | Actress Helen who was the first person to win the Triple Crown of Acting |
| 44% | STEVIENICKS | 11 | American singer and songwriter who became the first woman to be inducted twice into the Rock and Roll Hall of Fame: 2 wds. |
| 44% | COURIC | 6 | Journalist who was the first woman to guest-host "Jeopardy!" |
| 44% | EDITHWHARTON | 12 | 13-Across and 25-Across writer who was the first woman to win a Pulitzer Prize in Literature, for her 1920 novel "The Age of Innocence" (2 wds.) |
| 44% | REBA | 4 | Singer McEntire who was the first woman to play Colonel Sanders |
| 44% | KATHRYNBIGELOW | 14 | "The Hurt Locker" director who is the only woman to win the Best Director Oscar (2 wds.) |
| 44% | KAMALAHARRIS | 12 | Former California senator who is the first woman and first person of color to be inaugurated as vice president of the United States (2 wds.) |
| 44% | KATIECOURIC | 11 | Journalist who was the first woman to guest-host "Jeopardy!" (2 wds.) |
| 43% | NAOMAMPBELL | 11 | *Woman who was the first Black model to appear on the cover of Time |
| 43% | ROSA | 4 | Parks who was the first woman to lie in honor in the Capitol |
| 43% | EDITH | 5 | Wharton who was the first woman to win a Pulitzer Prize for fiction |
| 43% | RENO | 4 | Janet who was the first woman to serve as U.S. attorney general |
| 43% | OLGA | 4 | Korbut who was the first inductee to the International Gymnastics Hall of Fame |
| 43% | VINCE | 5 | Environmental journalist Gaia ___ who was the first woman to win the Royal Society Winton Prize for Science Books |
| 43% | MIA | 3 | Hamm who was the first woman inducted into the World Football Hall of Fame |