| 100% | ITSOVER | 7 | “You and I are done!” |
| 94% | ENDSIT | 6 | Says "You and I are done," e.g. |
| 81% | OURS | 4 | What things belonging to you and me are |
| 80% | WET | 3 | You and I get temperature, being soaked |
| 79% | ARE | 3 | I am, and you? |
| 77% | LIFE | 4 | "Tell me, what is it you plan to do / with your one wild and precious ___?": Mary Oliver |
| 75% | KISS | 4 | I am what you do under a mistletoe |
| 72% | WELLSPRING | 10 | "You and I are about to leap" |
| 72% | JOINTVENTURE | 12 | "My colleagues and I will do some exploratory work on your knee, in a ___," said the rheumatologist |
| 72% | ELLIEGOULDING | 13 | 15-Across and 29-Across singer whose hit single "Love Me Like You Do" was nominated for a Grammy Award (2 wds.) |
| 72% | ELLIEGOULDING | 13 | 14-Across and 45-Across singer whose hit single "Love Me Like You Do" was nominated for a Grammy Award (2 wds.) |
| 70% | ADEAR | 5 | "Would you be ___ and help me?" |
| 68% | EVER | 4 | "Why did I ___ doubt you?" ("You were right") |
| 68% | AUNT | 4 | I am the relative who pampers you with chocolates and ice cream. Who am I? |
| 68% | GRANDMA | 7 | I am the relative who bakes cookies and knits sweaters for you. Who am I? |
| 68% | AREWEREADY | 10 | "You and I gonna do this?" |
| 67% | APAL | 4 | "Be ___ and just give me a hand here, will you?" |
| 67% | DEN | 3 | I am the cozy room where you relax and watch your favorite shows. Who am I? |
| 67% | ROAR | 4 | "'Cause I am a champion, and you're gonna hear me ___!" (Katy Perry lyric) |
| 66% | US | 2 | You and me |
| 66% | WE | 2 | You and I |
| 66% | PERSONS | 7 | You and me |
| 66% | WINDOWDUMMY | 11 | "How did you know I was standing outside, Mr. Rickles?" |
| 66% | AREWEOK | 7 | "Do you and I need to clear the air?" |
| 65% | PAIR | 4 | You and me, say |
| 65% | MORTALS | 7 | You and me, presumably |
| 65% | PROTOPLASM | 10 | You and me, essentially |
| 65% | PEOPLE | 6 | You and me both! |
| 65% | XXXXXXXXXX | 10 | You and me, say |
| 65% | BAKEDACAKE | 10 | What I'd've done "if I knew you were comin' " |