| 100% | IROBOT | 6 | 1950 sci-fi fixup novel by Isaac Asimov that shares its title with a 2004 film starring Will Smith: 2 wds. |
| 40% | IRONMAN | 7 | 44-Across song that shares its title with a Robert Downey, Jr. superhero film: 2 wds. |
| 38% | NIGHTFALL | 9 | 1941 sci-fi short story by Isaac Asimov that was adapted into a 1988 film starring Sarah Douglas |
| 36% | LOVEYOU | 7 | "P.S. I ___," film based on a novel which shares its title with a 1962 song by The Beatles: 2 wds. |
| 35% | NAKEDSUN | 8 | "The ___," 1957 sci-fi novel by Isaac Asimov that was adapted into an episode of the TV series "Out of the Unknown": 2 wds. |
| 34% | MAN | 3 | "The Bicentennial ___," 1976 sci-fi novelette by Isaac Asimov that was adapted into a 1999 film starring Robin Williams |
| 33% | NAME | 4 | "Spell My ___ with an S," sci-fi short story by Isaac Asimov that was adapted into a 2014 short film directed by Samuel Ali |
| 32% | STRIPTEASE | 10 | Novel by 44-Across that was made into a movie starring Demi Moore: 2 wds. |
| 32% | THENAMESAKE | 11 | Debut novel by 25-Across/27-Across that was adapted as a film starring Kal Penn and directed by Mira Nair (2 wds.) |
| 32% | IROBOT | 6 | Sci-fi classic made into a 2004 film starring Will Smith |
| 31% | WOMENTALKING | 12 | Novel by 36-Across about an isolated Mennonite community in Bolivia that was adapted by 17-Across into a film starring Frances McDormand, Claire Foy, and Rooney Mara (2 wds.) |
| 30% | FIGHTCLUB | 9 | 1996 novel by Chuck Palahniuk featuring an unnamed protagonist, with a film adaptation starring Brad Pitt and Edward Norton: 2 wds. |
| 30% | PROUDMARY | 9 | Action film starring 15-Across and 45-Across that shares its name with a Tina Turner song (2 wds.) |
| 30% | CRASH | 5 | 2004 Oscar-winning film starring Sandra Bullock that shares its name with a 1996 erotic thriller film |
| 30% | WHITENOISE | 10 | Novel by 44-Across that was adapted as a 2022 film by Noah Baumbach (2 wds.) |
| 30% | IAM | 3 | "___ Legend," 2007 post-apocalyptic film starring Will Smith which is about a pandemic: 2 wds. |
| 29% | HOMEWARDBOUND | 13 | "___: The Incredible Journey," 1993 adventure comedy film starring Robert Hays which is about three pets that embark on a journey to reunite with their owners: 2 wds. |
| 29% | PRETTYWOMAN | 11 | 1990 Garry Marshall film starring 17-Across and 28-Across whose title was inspired by a Roy Orbison song (2 wds.) |
| 29% | TEXASRANGERS | 12 | MLB team that shares its name with a New York NHL team: 2 wds. |
| 29% | WINNIPEGJETS | 12 | NHL team that shares its name with a New York NFL team: 2 wds. |
| 29% | THEDRY | 6 | Novel by Australian author Jane Harper that was adapted into a movie starring Eric Bana: 2 wds. |
| 29% | DAVINCI | 7 | "The ___ Code," 2003 novel by Dan Brown that was made into a film: 2 wds. |
| 29% | THEHUNGERGAMES | 14 | Dystopian sci-fi adventure film series starring Jennifer Lawrence which has been adapted from a trilogy by Suzanne Collins: 3 wds. |
| 29% | IAM | 3 | "___ Legend," 2007 film starring Will Smith: 2 wds. |
| 28% | ETHANFROME | 10 | 1911 novel by 39-Across adapted as a film starring Liam Neeson as the title farmer in an unhappy marriage (2 wds.) |
| 28% | ALICECOOPER | 11 | American rock band that shares its name with a character from "Mayberry R.F.D.": 2 wds. |
| 28% | MOUNTAIN | 8 | "Cold ___," epic period film with a "frigid" title that is based on a novel by Charles Frazier |
| 28% | UNDERTHEBRIDGE | 14 | Novel by 47-Across that was adapted as a 2024 Hulu miniseries starring Lily Gladstone (3 wds.) |
| 28% | FIREFLYLANE | 11 | Bestselling novel by Kristin Hannah about two lifelong best friends that was adapted as a Netflix series starring 19-Across and 32-Across (2 wds.) |
| 28% | BASKETCASE | 10 | Novel by 44-Across that highlights a song by the same name cowritten with Warren Zevon: 2 wds. |