| 100% | ILOVELUCY | 9 | 1950s sitcom whose title character sells Vitameatavegamin in one episode: 3 wds. |
| 38% | ILOVELUCY | 9 | Classic sitcom whose title was written in cursive over a heart (3 wds.) |
| 35% | HOGANSHEROES | 12 | Classic CBS sitcom whose title character leads a group of World War II prisoners: 2 wds. |
| 34% | FRIENDS | 7 | NBC sitcom whose episode titles mostly started with "The One" |
| 34% | SEINFELD | 8 | Sitcom whose four main characters are convicted of a crime in the final episode |
| 33% | THENANNY | 8 | Sitcom whose title character was Fran Fine |
| 32% | DAWSONSCREEK | 12 | Classic high-school drama series on the WB whose title character lives near a stream in Capeside, Massachusetts: 2 wds. |
| 32% | ALF | 3 | 1980s sitcom whose title character was an alien |
| 32% | THENANNY | 8 | Nineties sitcom whose title character was Fran Fine |
| 32% | JEDGARHOOVER | 12 | Real-life FBI director and title character played by Leonardo DiCaprio in a 2011 film: 3 wds. |
| 31% | ROBERTDENIRO | 12 | "Joy" actor who plays the title character in 18-Across: 3 wds. |
| 30% | MISTERED | 8 | 1960s US television sitcom whose title character is a talking horse |
| 30% | REBA | 4 | 2000s WB/CW sitcom whose title character's last name was Hart |
| 30% | CRAIGOFTHECREEK | 15 | Cartoon whose title character lives in Herkleton, Maryland |
| 30% | HEDDAGABLER | 11 | Henrik Ibsen play whose title character manipulates others in order to fulfill her own desires: 2 wds. |
| 30% | ALF | 3 | 1980s sitcom whose title is written in capital letters |
| 29% | ALLIE | 5 | Title character in a 1980's sitcom |
| 29% | THEIDENTICALS | 13 | 2017 Elin Hilderbrand novel whose title characters are twin sisters: 2 wds. |
| 29% | DHARMA | 6 | Title character in a new 1997 ABC sitcom |
| 28% | ALLTHESTARS | 11 | 2018 Kendrick Lamar/SZA hit whose title includes things in the sky: 3 wds. |
| 28% | HAPPYDAYS | 9 | Sitcom whose 1978 episode "My Favorite Orkan" launched "Mork & Mindy" (2 wds.) |
| 28% | ALLIE | 5 | ___ Lowell, title character in a 1980's sitcom |
| 28% | MOTHERS | 7 | “Parallel ___” (2021 Pedro Almodóvar film whose title characters meet in a hospital room) |
| 28% | ICARLY | 6 | Nickelodeon sitcom whose episode titles all started with "i" |
| 28% | OGRE | 4 | The title character defeats one in "Puss in Boots" |
| 28% | APE | 3 | The title character in "Mighty Joe Young," for one |
| 28% | LINDALAVIN | 10 | Actress who played the title character on the sitcom "Alice": 2 wds. |
| 27% | ITWILLRAIN | 10 | 2011 Bruno Mars hit whose title ends with something wet: 3 wds. |
| 27% | JOHNNYBRAVO | 11 | Muscular title character in a 1997-2004 Cartoon Network series: 2 wds. |
| 27% | CHRISEVANS | 10 | "Knives Out" actor who voices the title character in "Lightyear" (2 wds.) |