| 100% | APLACE | 6 | 1970 novel by Melvyn Bragg, second in The Cumbrian Trilogy |
| 41% | CREDO | 5 | 1996 novel by Melvyn Bragg |
| 41% | ATIMETODANCE | 12 | 1990 novel by Melvyn Bragg |
| 40% | PLEXUS | 6 | 1953 novel by Henry Miller, second volume of trilogy The Rosy Crucifixion |
| 39% | TWOSISTERS | 10 | 1970 work by Gore Vidal subtitled A Novel in the Form of a Memoir |
| 39% | FORWEAREMANY | 12 | Second novel in the "Bobiverse" science-fiction series by 32-Across (4 wds.) |
| 38% | HIRED | 5 | & 14D The —, 1969 Melvyn Bragg novel; first part of The Cumbrian Trilogy |
| 37% | BRED | 4 | "What's ___ in the Bone" (second novel in Robertson Davies's Cornish Trilogy) |
| 36% | SUPREMACY | 9 | "The Bourne ___," second Jason Bourne novel written by Robert Ludlum in 1986 |
| 35% | ACLASHOFKINGS | 13 | Second novel in the epic fantasy series "A Song of Ice and Fire" by George R.R. Martin: 4 wds. |
| 35% | CHOLERA | 7 | Novel by García Márquez: Love in the Time of __ |
| 35% | MEDDLERS | 8 | The —, 1970 novel by Claire Rayner |
| 35% | KILLER | 6 | The —, 1970 novel by Colin Wilson |
| 35% | THEBLUESTEYE | 12 | 1970 novel by 43-Across about an African-American girl in 1940s Ohio (3 wds.) |
| 34% | LOVE | 4 | "___ in the Time of Cholera," novel by Gabriel Garcia Marquez |
| 34% | TRIPLEECHO | 10 | The —, 1970 novel by H E Bates |
| 34% | RELOADED | 8 | The Matrix __; second in the trilogy |
| 34% | LESS | 4 | Novel by Andrew Sean Greer that won the Pulitzer Prize in 2018 |
| 34% | OUT | 3 | "___ in the Country," 1970 environmental advocacy song by Three Dog Night |
| 34% | CHOLERA | 7 | "Love in the Time of ___," novel by Gabriel G. Marquez |
| 34% | INSURGENT | 9 | Second book in a trilogy by Veronica Roth |
| 33% | GIRLS | 5 | "Kiss the ___," second novel in the Alex Cross series by James Patterson |
| 33% | JOY | 3 | "___ in the Morning," novel by P.G. Wodehouse first published in 1946 |
| 33% | AUNTS | 5 | Dahlia and Agatha, in the Jeeves novels by P. G. Wodehouse |
| 33% | RYE | 3 | "The Catcher in the ___," novel by J.D. Salinger |
| 33% | DEADSIMPLE | 10 | 2005 novel by Peter James; first book in the Roy Grace series |
| 33% | FAIREST | 7 | 2006 novel by Gail Carson Levin set in the kingdom of Ayortha |
| 33% | PEQUOD | 6 | Ship in the Herman Melville novel Moby-Dick commanded by Captain Ahab |
| 33% | MONEYPENNY | 10 | Miss —, secretary to M in the James Bond novels by Ian Fleming |