| 100% | THECOSBYSHOW | 12 | 1984-1992 NBC sitcom set in Brooklyn: 3 wds. |
| 50% | STDENIS | 7 | "___ Medical" (NBC sitcom set in an Oregon hospital): 2 wds. |
| 49% | HORACEANDPETE | 13 | Web series set in a Brooklyn bar that costarred Edie Falco: 3 wds. |
| 49% | AVIEWFROM | 9 | With 23-Down, Arthur Miller play set in a Brooklyn waterfront neighborhood: 3 wds. |
| 47% | FRASIER | 7 | 1993-2004 NBC sitcom set in Seattle |
| 47% | APBIO | 5 | Patton Oswalt sitcom set in a high-school science class (3 wds.) |
| 47% | CHEERS | 6 | NBC sitcom set in a bar that starred Ted Danson |
| 46% | FRIENDS | 7 | 1994-2004 NBC sitcom set in New York City |
| 45% | ANGELASASHES | 12 | 1996 memoir set in Brooklyn and Ireland (2 wds.) |
| 44% | MALIBUCOUNTRY | 13 | Sitcom set in Southern California starring Reba McEntire: 2 wds. |
| 44% | DERRYGIRLS | 10 | Sitcom set in Northern Ireland featuring 1990s teenagers (2 wds.) |
| 44% | MADABOUTYOU | 11 | Sitcom set in New York City that featured Carol Burnett in a recurring role as Jamie's mother (3 wds.) |
| 43% | SUPERSTORE | 10 | NBC sitcom set at fictional big-box retailer Cloud 9 in St. Louis |
| 42% | ACHRISTMASSTORY | 15 | Holiday film set in Indiana: 3 wds. |
| 42% | FAMILYMATTERS | 13 | Sitcom set in Chicago that was a spin-off of "Perfect Strangers" (2 wds.) |
| 42% | THEGOLDBERGS | 12 | ABC sitcom set in the 1980s narrated by 44-Across (2 wds.) |
| 41% | THEGOODPLACE | 12 | NBC sitcom about the afterlife that starred Ted Danson: 3 wds. |
| 41% | SCHITTSCREEK | 12 | Sitcom set in Canada with a 2020 same-sex wedding between David and Patrick: 2 wds. |
| 41% | UPALLNIGHT | 10 | NBC sitcom starring 15-/50-Across as a new mom: 3 wds. |
| 41% | THEWATERDANCER | 14 | 2019 surrealist novel set in the antebellum South: 3 wds. |
| 40% | ANDYSAMBERG | 11 | Former "SNL" comedian who stars on a sitcom set in an NYPD precinct: 2 wds. |
| 40% | REC | 3 | "Parks and ___" (NBC sitcom set in Indiana, for short) |
| 40% | THEJEFFERSONS | 13 | Sitcom set in New York city that was a spin-off of "All in the Family" (2 wds.) |
| 40% | ABOUTABOY | 9 | Current NBC sitcom starring Minnie Driver as a single mom: 3 wds. |
| 39% | WHOSTHEBOSS | 11 | 1984-1992 sitcom featuring Tony Danza as housekeeper Tony Micelli (3 wds.) |
| 39% | ALLTHELIGHT | 11 | With 42-Across, Anthony Doerr novel set in WWII France: 3 wds. |
| 39% | THELAKEHOUSE | 12 | 2015 bestseller set in an abandoned estate by the water: 3 wds. |
| 39% | THEDUSTBOWL | 11 | 2012 documentary by 43-Across that was set in the 1930s: 3 wds. |
| 39% | FIELDOFDREAMS | 13 | 1989 Kevin Costner baseball film set in Iowa: 3 wds. |
| 39% | DERRYGIRLS | 10 | British sitcom set in Northern Ireland that starred 34-Across as Catholic school student Clare Devlin: 2 wds. |