| 100% | POLICEACADEMY | 13 | 1984 comedy starring Steve Guttenberg and Kim Cattrall that led to six sequels, a sitcom, and an animated series (2 wds.) |
| 57% | THEKARATEKID | 12 | 1984 drama starring Ralph Macchio and Pat Morita that led to four sequels, an animated series, and a Netflix series (2 wds.) |
| 52% | GHOSTBUSTERS | 12 | 1984 supernatural comedy starring Dan Aykroyd and Bill Murray that led to three sequels, a reboot film, and two animated series |
| 33% | SOUTHPARK | 9 | Animated series starring Trey Parker and Matt Stone that's named for a fictional town in Colorado: 2 wds. |
| 32% | GEORGELOPEZ | 11 | Comedian who starred in a self-titled sitcom from 2002 to 2007, and another that started in 2016: 2 wds. |
| 31% | CAFESOCIETY | 11 | A 2016 comedy by Woody Allen starring Steve Carell and Blake Lively: 2 wds |
| 31% | EVANALMIGHTY | 12 | 2007 comedy starring Steve Carell as a congressman who builds an ark: 2 wds. |
| 30% | BROADCITY | 9 | Comedy Central sitcom that starred Ilana Glazer and Abbi Jacobson: 2 wds. |
| 30% | BOJACKHORSEMAN | 14 | Netflix animated series about a washed-up sitcom star: 2 wds. |
| 30% | HALFMEN | 7 | "Two and a ___," an American sitcom starring Charlie Sheen: 2 wds |
| 30% | CRIMINALMINDS | 13 | FBI drama starring A.J. Cook, 15-Across, and 30-Across that was revived with an "Evolution" series (2 wds.) |
| 30% | SCHITTSCREEK | 12 | Comedy series starring Eugene Levy that's named for a fictional town in Canada: 2 wds. |
| 30% | ITHAD | 5 | "___ To Be You," a 2015 romantic comedy starring Cristin Milioti and Dan Soder: 2 wds. |
| 30% | INTRANSLATION | 13 | "Lost ___," a romantic comedy starring Bill Murray and Scarlett Johansson, that is considered one of the best movies of the 2000s: 2 wds. |
| 30% | JEANSMART | 9 | "Hacks" star who won an Emmy Award for Outstanding Lead Actress in a Comedy Series in 2022 (2 wds.) |
| 30% | COBRAKAI | 8 | Netflix series that is a sequel to the "Karate Kid" franchise: 2 wds. |
| 29% | CURBYOUR | 8 | With 38-Across, 2000-2024 HBO sitcom that centers around a comedy writer and his friends: 2 wds. |
| 29% | TROPICTHUNDER | 13 | 2008 comedy starring Jack Black as an actor forced to survive in a jungle: 2 wds. |
| 29% | INOBLIVION | 10 | "Living ___," independent dark comedy starring Peter Dinklage about an indie-filmmaker who tries to make a low budget movie: 2 wds. |
| 29% | EUGENELEVY | 10 | "Schitt's Creek" star who won the 2020 Emmy for Outstanding Lead Actor in a Comedy Series: 2 wds. |
| 29% | KNIGHTRIDER | 11 | 1982 American TV series about a crime fighter and an intelligent car starring David Hasselhoff: 2 wds. |
| 29% | LIGHTBULB | 9 | Notable invention from the 19th century, that brought steady light to households, and stands as a symbol of an idea: 2 wds. |
| 29% | FINDINGDORY | 11 | Animated comedy film starring Ellen DeGeneres, about an amnesiac fish who journeys to be reunited with her parents: 2 wds. |
| 28% | FRIENDSWITH | 11 | "___ Benefits," 2011 romantic comedy film that starred Justin Timberlake and Mila Kunis in the lead roles: 2 wds. |
| 28% | SAUSAGEPARTY | 12 | Animated adult comedy film starring Seth Rogen, about a sausage who tries to discover the truth about his existence: 2 wds. |
| 28% | RAMBLINGROSE | 12 | 1991 drama starring 16-Across and 39-Across that is the only film to have a mother and daughter both nominated for an Oscar for the same film (2 wds.) |
| 28% | DATENIGHT | 9 | 2010 comedy starring Steve Carell and Tina Fey: 2 wds. |
| 28% | THEMASK | 7 | Jim Carrey film that inspired an animated series featuring a supernatural face covering (2 wds.) |
| 28% | ANGELSIN | 8 | "___ America," 2003 miniseries starring Al Pacino for which he won an Emmy for Outstanding Lead Actor in a Limited Series: 2 wds. |
| 28% | TRAININGDAY | 11 | 2017 TV series that's based on a Denzel Washington movie and stars Bill Paxton as a cop: 2 wds. |