| 100% | REBECCAHOWE | 11 | 1987-93 "Cheers" role for Kirstie Alley (2 wds.) |
| 51% | CARLATORTELLI | 13 | 1982-93 "Cheers" role for Rhea Perlman (2 wds.) |
| 48% | HANKMOODY | 9 | "Californication" role for 32-Across: 2 wds. |
| 47% | BITPART | 7 | Insignificant role for a secondary actor: 2 wds. |
| 47% | ROBINHOOD | 9 | Role for Errol Flynn, Kevin Costner, and Russell Crowe: 2 wds. |
| 47% | FOXMULDER | 9 | "The X-Files" role for 32-Across: 2 wds. |
| 47% | SHELDONCOOPER | 13 | Emmy-winning role for 41-Across: 2 wds. |
| 45% | CENTERFIELDER | 13 | 14-Across's defensive role for most of his career: 2 wds. |
| 45% | MEGANPRICE | 10 | "Bridesmaids" role for Melissa McCarthy that was her film breakthrough: 2 wds. |
| 45% | FATHERMULCAHY | 13 | "M*A*S*H" role for William Christopher (1932-2016): 2 wds. |
| 44% | SHERMANPOTTER | 13 | "M*A*S*H" role for Harry Morgan: 2 wds. |
| 44% | HAWKEYEPIERCE | 13 | "M*A*S*H" role for Alan Alda: 2 wds. |
| 43% | DIANECHAMBERS | 13 | 1982-87 "Cheers" role for Shelley Long (2 wds.) |
| 43% | PRINCESSLEIA | 12 | Iconic role for 2-/51-Down |
| 42% | MOLLYFLYNN | 10 | Title role for Melissa McCarthy on a CBS sitcom that ended May 16, 2016: 2 wds. |
| 42% | JOSEPHINEBAKER | 14 | Emmy-winning title role for Lynn Whitfield in a 1991 HBO biopic about a dancer: 2 wds. |
| 41% | WINNIECOOPER | 12 | 16-Across role for 44-Across (2 wds.) |
| 40% | AGENTK | 6 | "Men in Black" role for Tommy Lee Jones (2 wds.) |
| 40% | JIMMYHOFFA | 10 | Oscar-nominated role for Al Pacino in 2020 (2 wds.) |
| 40% | HARRIETTUBMAN | 13 | Oscar-nominated role for Cynthia Erivo in 2020 (2 wds.) |
| 40% | FREDROGERS | 10 | Oscar-nominated role for Tom Hanks in 2020 (2 wds.) |
| 40% | RUBYBAPTISTE | 12 | "Colorful" role for Wunmi Mosaku on "Lovecraft Country" (2 wds.) |
| 40% | ROSENYLUND | 10 | "Colorful" role for Betty White on "Golden Girls" (2 wds.) |
| 40% | EMMAPEEL | 8 | "The Avengers" role for Uma Thurman and Diana Rigg (2 wds.) |
| 39% | DIRTYHARRY | 10 | Title role for 46-Across in a five-film franchise (2 wds.) |
| 39% | VIOLETPARR | 10 | "Colorful" voice role for Sarah Vowell in the "Incredibles" films (2 wds.) |
| 39% | ISEE | 4 | 2 wds for "I got it" |
| 38% | PRINCEHAMLET | 12 | Shakespearean Tony-winning stage role for 49-Across (2 wds.) |
| 38% | BRISCOEDARLING | 14 | "The Andy Griffith Show" role for 52-Across (2 wds.) |
| 38% | UNCLEJESSE | 10 | "The Dukes of Hazzard" role for 52-Across (2 wds.) |