| 100% | MURPHYBROWN | 11 | 1988-1998 CBS sitcom on which 28-Across played the title news anchor: 2 wds. |
| 45% | LINDALAVIN | 10 | Actress who played the title character on the sitcom "Alice": 2 wds. |
| 45% | THEMANDALORIAN | 14 | Disney+ space western on which 19-Across plays the title character: 2 wds. |
| 45% | CAMILLERAZAT | 12 | Actress who plays the title character's new friend on 46-Across (2 wds.) |
| 42% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |
| 42% | BOSTONLEGAL | 11 | 2004-2008 spin-off of "The Practice" on which 28-Across played partner Shirley Schmidt: 2 wds. |
| 41% | RAMONRODRIGUEZ | 14 | "Charlie's Angels" actor who plays the title role on 16-Across: 2 wds. |
| 41% | ROBERTYOUNG | 11 | He starred as the title character on 28-Across: 2 wds. |
| 40% | JAMESMCAVOY | 11 | "X-Men: Apocalypse" star who played the title character of 28-Across in a 2015 movie: 2 wds. |
| 40% | THEOFFICE | 9 | Sitcom on which Steve Carell played Michael Scott: 2 wds. |
| 40% | EMMANUELLEWIS | 13 | Actor who played the title character on "Webster": 2 wds. |
| 40% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 40% | LIEVSCHREIBER | 13 | "Spotlight" actor who has been nominated for three Emmys for playing the title role on 43-Across: 2 wds. |
| 39% | LILYCOLLINS | 11 | Actress who plays the title character on 46-Across (2 wds.) |
| 39% | KENNEDYMCMANN | 13 | Actress who plays the title role on "Nancy Drew": 2 wds. |
| 39% | BARBARABARRIE | 13 | "Breaking Away" actress who played the title character's Nana on 46-Across (2 wds.) |
| 39% | REBECCABREEDS | 13 | "Pretty Little Liars" actress who plays the title FBI agent on 34-Across (2 wds.) |
| 39% | DONJOHNSON | 10 | "Miami Vice" actor who played the title character on 40-Across (2 wds.) |
| 39% | PATRICKSTEWART | 14 | "X-Men" actor who plays the title role on 50-Across (2 wds.) |
| 39% | LOUISAHARLAND | 13 | "Derry Girls" actress who plays the title character on 44-Across (2 wds.) |
| 39% | TOMHIDDLESTON | 13 | "Kong: Skull Island" star who plays the title character on "Loki": 2 wds. |
| 38% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 38% | BIGBANG | 7 | "The ___ Theory," sitcom on which you would hear 15-Across: 2 wds. |
| 38% | GOODOMENS | 9 | Amazon series on which 31-Across plays the demon Crowley: 2 wds. |
| 38% | BILLYMADISON | 12 | 1995 classroom comedy in which 29-Across played the title role: 2 wds. |
| 38% | HAPPYGILMORE | 12 | 1996 sports comedy in which 29-Across played the title role: 2 wds. |
| 37% | EDDIEMURPHY | 11 | "Coming to America" actor who played the title role in 1998's "Dr. Dolittle": 2 wds. |
| 37% | BILLHADER | 9 | Former "Saturday Night Live" cast member who plays the title role on 4-Across (2 wds.) |
| 37% | RAMONRODRIGUEZ | 14 | "Charlie's Angels" actor who plays the title GBI special agent on 50-Across (2 wds.) |
| 37% | CRIMINALMINDS | 13 | CBS drama on which Aisha Tyler played forensic psychologist Dr. Tara Lewis: 2 wds. |