| 100% | MYST | 4 | 1990s computer game named after the fictional island where it was set |
| 49% | FALLS | 5 | "Gravity ___," animated mystery show named after the fictional town it is set in |
| 47% | TWIN | 4 | "___ Peaks," mystery series named after the fictional Washington town it is set in |
| 41% | CREEK | 5 | "Schitt's ___," comedy sitcom named after the small town it is set in |
| 40% | ROCK | 4 | "30 ___," workplace sitcom named after the real-life NYC building it is set in |
| 40% | PLACE | 5 | "Melrose ___," '90s soap opera named after the trendy Los Angeles neighborhood it is set in |
| 39% | ADELPHI | 7 | Long Island university named for the Brooklyn street where it was founded |
| 37% | MYST | 4 | 1990s computer game set on an island |
| 35% | QUAHOG | 6 | The fictional city where Family Guy is set |
| 35% | IRE | 3 | Island where the film "Belfast" is set: Abbr. |
| 35% | GATORADE | 8 | Drink named after the football team it was originally tested on |
| 34% | TANDOORI | 8 | ___ chicken (Indian dish named after the clay oven it is prepared in) |
| 34% | SEATTLE | 7 | "Sleepless in ___," 1993 film named after the city where the Space Needle is located |
| 33% | ARENDELLE | 9 | Fictional kingdom where the movie Frozen is set |
| 33% | KONG | 4 | "King ___," 2005 film that is set on the fictional Skull Island |
| 33% | CROMAGNON | 9 | Prehistoric hominid named for the French cave where it was first discovered |
| 33% | GENOA | 5 | Where the guy they named Columbus Day after was born |
| 33% | OPERATION | 9 | Game where the "board" is a man named Cavity Sam |
| 32% | ISLANUBLAR | 10 | The fictional Central American island in Costa Rica which is the setting for 26a: 2 wds. |
| 32% | HOWLER | 6 | Monkey that is named after the loud noise it makes |
| 32% | CRANIUM | 7 | Board game named after the skull |
| 31% | PACHISI | 7 | Game named after the Hindi word for "twenty-five" |
| 31% | SPA | 3 | Place where relaxation is the name of the game |
| 31% | WATERGATE | 9 | Political scandal named after the hotel complex where some of its key events occurred |
| 31% | YSER | 4 | WWI battle named after the river where the German Army was obstructed by opening sluices and flooding land to the west |
| 31% | SCYTHE | 6 | Board game named after the reaper's weapon |
| 30% | EURO | 4 | Money named for the continent where it is used |
| 30% | BRIE | 4 | Region where Meaux is located that has a cheese named after it |
| 30% | CDS | 3 | 1990s computer games were sold on them: Abbr. |
| 30% | SCANDIUM | 8 | Rare-earth element named after where it was discovered |