| 100% | THENANNY | 8 | 1990s sitcom starring Fran Drescher: 2 wds. |
| 59% | ROSEANNEBARR | 12 | 1990s sitcom star who was the subject of a Comedy Central Roast in 2012: 2 wds. |
| 51% | NANNY | 5 | "The ___," sitcom starring Fran Drescher that featured an animated episode in season 3 |
| 50% | MODERNFAMILY | 12 | ABC sitcom starring 49-Across: 2 wds. |
| 48% | MADABOUTYOU | 11 | Recently rebooted 1990s sitcom starring Helen Hunt and Paul Reiser: 3 wds. |
| 48% | LIVINGSINGLE | 12 | 1990s sitcom in which Queen Latifah played Khadijah: 2 wds. |
| 47% | FULLHOUSE | 9 | 1990s sitcom featuring Uncle Jesse, played by John Stamos: 2 wds. |
| 47% | SISTERSISTER | 12 | '90s sitcom starring Tia and Tamera Mowry: 2 wds. |
| 47% | ATO | 3 | "___ Z" (NBC sitcom starring Ben Feldman): 2 wds. |
| 46% | ANGIETRIBECA | 12 | TBS sitcom starring 32-Across as a police detective: 2 wds. |
| 46% | THEUPSHAWS | 10 | Netflix sitcom starring Kim Fields as family matriarch Regina: 2 wds. |
| 46% | PUNKYBREWSTER | 13 | Chicago-based 1984-1988 sitcom starring Soleil Moon Frye: 2 wds. |
| 46% | UGLYBETTY | 9 | 2000s sitcom starring 35-Across as a magazine assistant: 2 wds. |
| 46% | JERRYSEINFELD | 13 | Brooklyn-born comedian and namesake of a 1990s sitcom: 2 wds. |
| 46% | BOJACKHORSEMAN | 14 | Netflix animated series about a washed-up sitcom star: 2 wds. |
| 46% | ROSEANNEBARR | 12 | Title star of a 1990s sitcom who was the honoree of a 2012 Comedy Central roast: 2 wds. |
| 45% | BOSOMBUDDIES | 12 | 1980-1982 sitcom starring Tom Hanks, before he was famous: 2 wds. |
| 45% | SAMANTHAWHO | 11 | 2007-2009 ABC sitcom starring Christina Applegate as a recovering amnesiac: 2 wds. |
| 45% | THEOFFICE | 9 | Emmy-winning sitcom starring Mindy Kaling (birthday today) as Kelly Kapoor": 2 wds. |
| 45% | SCHITTSCREEK | 12 | 2015-2020 sitcom starring Catherine O'Hara as actress Moira Rose: 2 wds. |
| 45% | FULLERHOUSE | 11 | Netflix reboot of a 1990s sitcom about a San Francisco family: 2 wds. |
| 44% | ATA | 3 | "One Day ___ Time" (rebooted sitcom starring Rita Moreno): 2 wds. |
| 44% | FAMILYMATTERS | 13 | Chicago-based 1989-1998 sitcom starring Jaleel White: 2 wds. |
| 44% | GOODTIMES | 9 | Chicago-based 1974-1979 sitcom starring Esther Rolle: 2 wds. |
| 44% | THENANNY | 8 | 1993-1999 Fran Drescher show where her character once competed on "Jeopardy!": 2 wds. |
| 44% | TVCAMERA | 8 | What sitcom stars and reporters stand in front of to be recorded: 2 wds. |
| 43% | SUDDENLYSUSAN | 13 | 1996-2000 sitcom starring 15-Across as a magazine writer in San Francisco: 2 wds. |
| 43% | MAJORDAD | 8 | 1989-1993 CBS sitcom starring Gerald McRaney as a military man with stepkids: 2 wds. |
| 43% | MCHALESNAVY | 11 | 1962-1966 sitcom starring Ernest Borgnine as lieutenant commander of a military vessel: 2 wds. |
| 43% | BARR | 4 | 1990s sitcom star Roseanne |