| 100% | BEAST | 5 | 2000s sitcom with Alexander Armstrong and Doon Mackichan |
| 33% | NEWHART | 7 | Sitcom with Dick and Joanna |
| 33% | MASH | 4 | Sitcom with Radar and Klinger |
| 33% | MASH | 4 | Sitcom with Hawkeye and Radar |
| 32% | SAMANTHAWHO | 11 | 2000s sitcom about a woman with amnesia |
| 32% | {BOY/GIRL}MEETSWORLD | 20 | Sitcom with the characters Cory and Topanga |
| 32% | FRIENDS | 7 | Sitcom with Rachel, Monica and Phoebe |
| 32% | PARKS | 5 | Sitcom with Amy Poehler; __ and Recreation |
| 31% | FABULOUS | 8 | Absolutely __, British sitcom with Edina and Patsy |
| 31% | TAXI | 4 | Sitcom with such characters as Elaine Nardo and Latka Gravas |
| 30% | SEINFELD | 8 | US sitcom with Jerry, Elaine, George and Kramer |
| 30% | FATHERKNOWSBEST | 15 | Classic sitcom with kids called Princess, Bud and Kitten |
| 29% | TAXI | 4 | Classic sitcom with Judd Hirsch, Tony Danza, and Danny DeVito |
| 29% | FOOLSRUSHIN | 11 | With 36- and 59-Across, words of Alexander Pope |
| 29% | ESSES | 5 | What sitcoms always begin and end with? |
| 28% | ALDRIN | 6 | Astronaut with Armstrong and Collins |
| 28% | GRACE | 5 | Name with Will and Frankie in sitcom titles |
| 28% | HAPPYDAYS | 9 | 1974-1984 sitcom with Fonzie, Richie, and Potsie: 2 wds. |
| 27% | TRUTV | 5 | Cable channel with reruns of sitcoms and reality shows |
| 27% | NEKOCASE | 8 | 2000s rock singer with the hit albums "Hell-On" and "Middle Cyclone" |
| 26% | HOTINCLEVELAND | 14 | *TV Land sitcom with Betty White and Valerie Bertinelli |
| 26% | THAT | 4 | With 15- and 26-Across, former Fox sitcom focused on a certain decade, literally |
| 26% | NATASHA | 7 | ___ Bedingfield, 2000s pop star with the hits "Unwritten" and "Pocketful of Sunshine" |
| 26% | DERRY | 5 | "___ Girls," Channel 4 sitcom with female leads that's set in Northern Ireland and won multiple awards |
| 25% | TERRYSCOTT | 10 | Co-star with Hugh Lloyd of 1960s BBC TV sitcom Hugh and I |
| 25% | NBC | 3 | Network with the sitcoms "Grand Crew" and "Kenan" |
| 25% | WHATA | 5 | With 15 and 20 Across, a 1967 song sung by Louis Armstrong in "Good Morning, Vietnam" |
| 25% | SCHITTSCREEK | 12 | Sitcom set in Canada with a 2020 same-sex wedding between David and Patrick: 2 wds. |
| 25% | NEILS | 5 | Armstrong and Diamond |
| 25% | NEILS | 5 | Armstrong and Sedaka |