| 100% | REBA | 4 | 2001-2007 sitcom about a single mother in Houston |
| 55% | MOM | 3 | 2013 modern sitcom about a single mother which was filmed with a live audience |
| 52% | ONEDAYATATIME | 13 | Norman Lear sitcom about a single mom and her daughters, revived in 2017: 5 wds. |
| 44% | ALICE | 5 | Old sitcom about a single mom working at a Phoenix diner |
| 43% | LILYMUNSTER | 11 | Mother in a 1960's sitcom |
| 43% | GHOSTS | 6 | Sitcom about a couple living in a haunted house |
| 41% | JETSONS | 7 | "The ___," Hanna-Barbera animated sitcom about a family in the future |
| 41% | CATHY | 5 | Comic strip about a single woman who finally married Irving in 2005 |
| 41% | REBA | 4 | Single mom in a 2000s sitcom |
| 40% | THEGOLDBERGS | 12 | ABC sitcom about a geeky boy growing up in the 1980s: 2 wds. |
| 40% | ENRON | 5 | Houston-based company in a 2001 scandal |
| 40% | GILMOREGIRLS | 12 | Quirky 2000-2007 drama about a mother and daughter living in Stars Hollow, Connecticut: 2 wds. |
| 40% | CROWD | 5 | "The IT ___," sitcom about tech support in a dysfunctional company |
| 39% | UNBREAKABLE | 11 | With 24-Across, Netflix sitcom about a cult survivor starting over in New York City |
| 39% | ENRON | 5 | Houston-based energy giant involved in a 2001 scandal |
| 38% | SCHITTSCREEK | 12 | Pop TV sitcom about a formerly rich family forced to live in a run-down motel: 2 wds. |
| 38% | EMERIL | 6 | Short-lived 2001 sitcom about a chef |
| 37% | GOLDEN | 6 | "The ___ Girls," '80s sitcom about four older women who share a house in Florida |
| 37% | CROWNED | 7 | "___," TV show about mother-daughter teams competing in a beauty pageant |
| 36% | ONEDAYATATIME | 13 | CBS sitcom about a divorced mother raising two teenaged daughters that ran from 1975 to 1984: 5 wds. |
| 36% | FRASIER | 7 | Sitcom about a Seattle psychotherapist |
| 36% | REBA | 4 | Sitcom about a Texas soccer mom |
| 35% | REBA | 4 | 2001-2007 sitcom starring a country singer |
| 35% | SUBURGATORY | 11 | Former ABC sitcom, about life in a town outside New York City, that featured Alan Tudyk |
| 35% | ONEDAYATATIME | 13 | Netflix reboot of a 1970s sitcom about a single mom's family: 5 wds. |
| 35% | JETSONS | 7 | "The ___," animated sci-fi sitcom about space that revolves around a high-tech family who live in Orbit City |
| 35% | LARRY | 5 | "The ___ Sanders Show," sitcom about the happenings in the office of a late-night talk show starring Garry Shandling |
| 34% | ELLEN | 5 | 1990s sitcom about a bookstore owner |
| 34% | THEBRADYBUNCH | 13 | Classic sitcom about a blended family |
| 34% | THEOFFICE | 9 | TV sitcom about a company workplace |