| 100% | IRIS | 4 | 2001 biopic about writer Murdoch, in which 15-Across played the title role (and received a Best Actress nomination) |
| 44% | ROD | 3 | Actor Steiger who played the title role of 15-Across in a 1959 biopic |
| 39% | BEN | 3 | Actor Gazzara who played the title role of 15-Across in a 1975 film |
| 36% | IRIS | 4 | 2001 film in which Kate Winslet and Judi Dench played the title role |
| 36% | PHILOMENA | 9 | 2013 film for which 15-Across received a Best Actress nomination |
| 36% | GRETAGARBO | 10 | Actress who played the title role in films Anna Karenina and Ninotchka |
| 36% | AMYPOEHLER | 10 | Actress who played the role of Leslie Knope in "Parks and Recreation", a role she is best-known for: 2 wds. |
| 35% | SONJASOHN | 9 | "The Wire" actress who plays Nancy, the title boxer's mother, in a 2023 biopic about 40-Across (2 wds.) |
| 35% | OTOOLE | 6 | Peter who played the title role in 15-/50-Across |
| 34% | LOLITA | 6 | & 25A Actress who played the title role in 1989 biopic Blaze |
| 34% | ANYA | 4 | Actress who played the title role in 2016 sci-fi and horror film Morgan (4,6-3) |
| 34% | AMYADAMS | 8 | Best Actress in a Supporting Role Oscar nominee for The Master, Junebug, Doubt and The Fighter |
| 34% | RICHARDSON | 10 | Miranda —, Best Actress in a Leading Role Oscar nominee for biopic Tom and Viv |
| 34% | GRAHAME | 7 | Gloria —, Best Actress in a Supporting Role Oscar winner for The Bad and the Beautiful |
| 34% | ALI | 3 | 2001 biopic starring Will Smith in the title role of a famous boxer |
| 33% | HAYEK | 5 | Salma —, actress who played the title role in 2002 biopic Frida |
| 33% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |
| 33% | THURGOOD | 8 | With 52-Across, Supreme Court justice who's the title role played by Chadwick Boseman in a 2017 biopic |
| 33% | ULLMANN | 7 | Liv —, Best Actress in a Leading Role Oscar nominee for Face to Face and The Emigrants |
| 33% | BESTACTOR | 9 | Academy Award category in which 15-Across received a nomination for 36-Across: 2 wds. |
| 33% | GARBO | 5 | Greta —, actress who played the title role in films Anna Karenina and Ninotchka |
| 33% | PATTINSON | 9 | Robert who plays the title role in 22 Across |
| 33% | DAWNFRENCH | 10 | Comedienne and actress who played the title role in BBC TV sitcom The Vicar of Dibley |
| 33% | PROVINE | 7 | Dorothy —, actress who played the title role in 1958 biopic The Bonnie Parker Story |
| 32% | RITTER | 6 | Thelma —, Best Actress in a Supporting Role Oscar nominee for Pillow Talk, All About Eve and four other films |
| 32% | HAYWORTH | 8 | Rita —, actress who played the title role in films Miss Sadie Thompson, Gilda and Salome |
| 32% | CRAIG | 5 | Wendy —, actress who played the title role in 1970s ITV sitcom And Mother Makes Three |