| 100% | SAMANTHAWHO | 11 | 2007-2009 ABC sitcom starring Christina Applegate as a recovering amnesiac: 2 wds. |
| 50% | MARRIEDWITH | 11 | With 44-Across, long-running Fox comedy starring Christina Applegate as a sex-obsessed teenager: 2 wds. |
| 43% | DEADTOME | 8 | Netflix dark comedy series starring Christina Applegate as a widow: 3 wds. |
| 41% | ANGIETRIBECA | 12 | TBS sitcom starring 32-Across as a police detective: 2 wds. |
| 41% | UGLYBETTY | 9 | 2000s sitcom starring 35-Across as a magazine assistant: 2 wds. |
| 40% | COUGARTOWN | 10 | 2009-2015 ABC/TBS sitcom that starred "Friends" alum Courteney Cox as a single mom on the dating scene: 2 wds. |
| 39% | APBIO | 5 | Sitcom that starred Glenn Howerton as a high school science teacher: 2 wds. |
| 39% | SUDDENLYSUSAN | 13 | 1996-2000 sitcom starring 15-Across as a magazine writer in San Francisco: 2 wds. |
| 39% | THERICHES | 9 | 2007-2008 FX drama starring Minnie Driver as a con artist: 2 wds. |
| 38% | MODERNFAMILY | 12 | ABC sitcom starring 49-Across: 2 wds. |
| 38% | EVANALMIGHTY | 12 | 2007 comedy starring Steve Carell as a congressman who builds an ark: 2 wds. |
| 37% | PARTYDOWN | 9 | 2009-2010 Starz sitcom with Adam Scott as a cater-waiter: 2 wds. |
| 36% | MAJORDAD | 8 | 1989-1993 CBS sitcom starring Gerald McRaney as a military man with stepkids: 2 wds. |
| 36% | EXTENDEDFAMILY | 14 | NBC sitcom starring Jon Cryer as Jim, a man raising kids with his ex-wife Julia: 2 wds. |
| 36% | MCHALESNAVY | 11 | 1962-1966 sitcom starring Ernest Borgnine as lieutenant commander of a military vessel: 2 wds. |
| 35% | ONTV | 4 | Currently playing, as a sitcom: 2 wds. |
| 35% | THEGOLDBERGS | 12 | ABC sitcom about a geeky boy growing up in the 1980s: 2 wds. |
| 35% | THEMIDDLE | 9 | 2009-2018 ABC sitcom about an Indiana family, or a 2018 song by Zedd, Maren Morris, and Grey: 2 wds. |
| 34% | ONTV | 4 | Airing or currently playing, as a sitcom: 2 wds. |
| 34% | TROPHYWIFE | 10 | ABC sitcom starring Malin Akerman and Bradley Whitford which was canceled after one season: 2 wds. |
| 34% | KEVINPROBABLY | 13 | With 33-Across, ABC series starring Jason Ritter as a man tasked with a heavenly mission: 2 wds. |
| 34% | THEOFFICE | 9 | Emmy-winning sitcom starring Mindy Kaling (birthday today) as Kelly Kapoor": 2 wds. |
| 33% | SAVEDBYTHEBELL | 14 | Teen sitcom starring 53-Across as A.C. Slater (4 wds.) |
| 33% | BIGBANGTHEORY | 13 | CBS sitcom starring Jim Parsons as a brainy Caltech physicist, with "The": 3 wds. |
| 32% | CROSSINGJORDAN | 14 | 2001-2007 NBC show starring Jill Hennessy as a pathologist: 2 wds. |
| 32% | THEUPSHAWS | 10 | Netflix sitcom starring Kim Fields as family matriarch Regina: 2 wds. |
| 32% | THEFIGHTER | 10 | 2010 movie starring Mark Wahlberg as a boxer: 2 wds. |
| 32% | HOCUSPOCUS | 10 | 1993 film starring Bette Midler as a witch: 2 wds. |
| 32% | JEFFGOLDBLUM | 12 | Actor famous for "Jurassic Park" who appeared as a guest star on "Friends": 2 wds. |
| 32% | ABOUTABOY | 9 | Current NBC sitcom starring Minnie Driver as a single mom: 3 wds. |