| 100% | KNOCKEDUP | 9 | 2007 comedy starring Seth Rogen and Katherine Heigl as reluctant parents: 2 wds. |
| 52% | KNOCKEDUP | 9 | 2007 comedy starring Paul Rudd and Seth Rogen: 2 wds. |
| 47% | KNOCKEDUP | 9 | Comedy starring Seth Rogen and 47-Across (2 wds.) |
| 39% | EVANALMIGHTY | 12 | 2007 comedy starring Steve Carell as a congressman who builds an ark: 2 wds. |
| 37% | NEIGHBORS | 9 | Bromantic comedy starring Seth Rogen and 49-Across |
| 37% | NEIGHBORS | 9 | 2014 fraternity comedy starring Seth Rogen and 49-Across |
| 33% | EVANALMIGHTY | 12 | 2007 comedy sequel starring Steve Carell: 2 wds. |
| 32% | FREAKSANDGEEKS | 14 | NBC drama series starring Seth Rogen and James Franco which was canceled after one season: 3 wds. |
| 32% | DANINREALLIFE | 13 | 2007 comedy-drama starring Steve Carell as a widowed advice columnist: 4 wds. |
| 32% | LORENZOSOIL | 11 | 1992 film starring Nick Nolte and Susan Sarandon as parents of a sick boy: 2 wds. |
| 32% | SAUSAGEPARTY | 12 | Animated adult comedy film starring Seth Rogen, about a sausage who tries to discover the truth about his existence: 2 wds. |
| 31% | UNCLEBUCK | 9 | 1989 John Hughes comedy starring John Candy as a crude babysitter: 2 wds. |
| 31% | EASYA | 5 | 2010 comedy starring Emma Stone as a high-schooler: 2 wds. |
| 31% | HONEYDONT | 9 | 2025 black comedy starring Margaret Qualley as a private investigator: 2 wds. |
| 31% | NIGHTSCHOOL | 11 | Comedy film starring 15-Across and 45-Across as dropouts working toward a GED (2 wds.) |
| 30% | KNOCKED | 7 | "___ Up," 2007 romantic comedy film directed Judd Apatow starring Seth Rogen and Paul Rudd |
| 30% | DATENIGHT | 9 | 2010 comedy starring Steve Carell and Tina Fey: 2 wds. |
| 30% | BADTEACHER | 10 | 2011 comedy starring Justin Timberlake and Cameron Diaz: 2 wds. |
| 30% | RIDEALONG | 9 | 2014 comedy starring Ice Cube and Kevin Hart: 2 wds. |
| 30% | EASYA | 5 | 2010 comedy starring Emma Stone and Penn Badgley: 2 wds. |
| 30% | FREAKDANCE | 10 | 2011 comedy starring Amy Poehler and Matt Besser: 2 wds. |
| 30% | OHGOD | 5 | 1977 comedy starring John Denver and George Burns: 2 wds. |
| 30% | ENCINOMAN | 9 | 1992 comedy starring Brendan Fraser as a frozen caveperson come back to life: 2 wds. |
| 30% | THEFAVOURITE | 12 | 2018 dark comedy starring Emma Stone as a beloved servant to Queen Anne: 2 wds. |
| 30% | ROLEMODELS | 10 | 2008 comedy starring Paul Rudd and Seann William Scott: 2 wds. |
| 30% | HAPPYGILMORE | 12 | 1996 comedy starring Adam Sandler as a hockey player who takes up professional golf: 2 wds. |
| 30% | TROPICTHUNDER | 13 | 2008 comedy starring Jack Black as an actor forced to survive in a jungle: 2 wds. |
| 30% | QUIZLADY | 8 | 2023 Hulu comedy starring 16-Across as the sister of a game show fanatic: 2 wds. |
| 29% | BLUESBROTHERS | 13 | 1980 comedy starring John Belushi and Dan Aykroyd, with "The": 2 wds. |