| 100% | JULIACHILD | 10 | 2009 title chef played by Meryl Streep |
| 51% | GRAHAM | 6 | Publisher Katharine played by Meryl Streep in "The Post" |
| 50% | ORLEAN | 6 | Author Susan played by Meryl Streep in 2002's "Adaptation" |
| 50% | ISAK | 4 | Writer Dinesen played by Meryl Streep in "Out of Africa" |
| 46% | AMELIA | 6 | Title role played by Hilary Swank in a 2009 biopic |
| 45% | SOPHIESCHOICE | 13 | 1982 film where Kevin Kline and a Holocaust survivor played by Meryl Streep are a couple: 2 wds. |
| 41% | OSCAR | 5 | Award won three times by Meryl Streep |
| 41% | OSCAR | 5 | Statuette won three times by Meryl Streep |
| 40% | JULIA | 5 | Child played by Meryl |
| 39% | SOPHIE | 6 | Meryl Streep title role |
| 38% | KAREN | 5 | Silkwood portrayed by Meryl Streep in “Silkwood” |
| 37% | SOPHIE | 6 | Meryl Streep's 1982 title role |
| 37% | ULEE | 4 | Title beekeeper played by Peter Fonda |
| 37% | BOSCH | 5 | Title cop played by Titus Welliver |
| 37% | EVE | 3 | Title character played by Sandra Oh |
| 37% | SARA | 4 | Title sister played by Shirley MacLaine, 1970 |
| 36% | HEIDI | 5 | Title heroine played by Shirley Temple in 1937 |
| 36% | SERPICO | 7 | Title cop played by Al Pacino in 1973 |
| 36% | ORLEAN | 6 | Author played by Streep in ''Adaptation'' |
| 36% | ORLEAN | 6 | Novelist played by Streep in ''Adaptation'' |
| 36% | JULIACHILD | 10 | 2009 Meryl Streep role |
| 36% | SOS | 3 | Song performed by Meryl Streep and Pierce Brosnan in "Mamma Mia!" |
| 35% | ANNIE | 5 | Title character played by Sarah Jessica Parker on Broadway |
| 35% | DEVIL | 5 | Wears Prada in Meryl Streep movie title |
| 35% | RICHARDCASTLE | 13 | Title TV novelist/sleuth played by 51-Across on ABC from 2009 to 2016 (2 wds.) |
| 35% | NUNS | 4 | Meryl Streep and Amy Adams played them in "Doubt" (2008) |
| 35% | LOIS | 4 | Title reporter played by Elizabeth on a 2020s CW series |
| 35% | LILO | 4 | Title role played by Maia Kealoha in a 2025 remake |
| 35% | BILKO | 5 | Title sergeant played by Steve Martin in a 1996 comedy |
| 35% | NORA | 4 | TV title character played by Awkwafina |