| 100% | THEHEAT | 7 | 2013 action comedy starring Melissa McCarthy and Sandra Bullock: 2 wds. |
| 67% | HEAT | 4 | "The ___," 2013 action comedy film starring Melissa McCarthy and Sandra Bullock |
| 52% | THUNDERFORCE | 12 | Superhero comedy starring Melissa McCarthy, 18-Across, and 29-Across (2 wds.) |
| 44% | IDENTITY | 8 | & 22A 2013 film comedy starring Jason Bateman and Melissa McCarthy |
| 44% | THEBOSS | 7 | 2016 film comedy starring Melissa McCarthy and Kristen Bell |
| 43% | TRUELIES | 8 | 1994 action comedy starring Arnold Schwarzenegger as a secret agent and Jamie Lee Curtis as his wife: 2 wds. |
| 43% | THENET | 6 | 1995 cyberspace action film starring Sandra Bullock: 2 wds. |
| 42% | THEPROPOSAL | 11 | Romcom starring Ryan Reynolds and Sandra Bullock which grossed $317 million worldwide in 2009: 2 wds. |
| 42% | THEHANGOVER | 11 | With 44-Across, 2013 buddy comedy with Melissa McCarthy: 2 wds. |
| 42% | SPY | 3 | 2015 action and comedy film starring Melissa McCarthy |
| 42% | THEHEAT | 7 | 2013 Sandra Bullock/Melissa McCarthy comedy |
| 42% | THEA | 4 | "___-team," action comedy film starring Liam Neeson and Bradley Cooper: 2 wds. |
| 39% | TROPICTHUNDER | 13 | Action comedy film starring Ben Stiller, Robert Downey Jr. and Jack Black: 2 wds. |
| 39% | COPOUT | 6 | 2010 action comedy directed by Kevin Smith, starring Bruce Willis and Tracy Morgan: 2 wds. |
| 38% | BRIDESMAIDS | 11 | 2011 comedy film starring Melissa McCarthy and Maya Rudolph |
| 37% | BOUNTYHUNTER | 12 | "The ___," 2010 action comedy film directed by Andy Tennant starring Jennifer Aniston and Gerard Butler: 2 wds. |
| 37% | GANGSTERSQUAD | 13 | 2013 crime film starring Ryan Gosling and Emma Stone: 2 wds. |
| 36% | LIFEOFTHEPARTY | 14 | New comedy film starring Melissa McCarthy: 4 wds. |
| 36% | DATENIGHT | 9 | 2010 comedy starring Steve Carell and Tina Fey: 2 wds. |
| 36% | KNOCKEDUP | 9 | 2007 comedy starring Paul Rudd and Seth Rogen: 2 wds. |
| 36% | BADTEACHER | 10 | 2011 comedy starring Justin Timberlake and Cameron Diaz: 2 wds. |
| 36% | RIDEALONG | 9 | 2014 comedy starring Ice Cube and Kevin Hart: 2 wds. |
| 36% | EASYA | 5 | 2010 comedy starring Emma Stone and Penn Badgley: 2 wds. |
| 36% | FREAKDANCE | 10 | 2011 comedy starring Amy Poehler and Matt Besser: 2 wds. |
| 36% | OHGOD | 5 | 1977 comedy starring John Denver and George Burns: 2 wds. |
| 36% | BADBOYS | 7 | Action comedy movie directed by Michael Bay about two detectives starring Will Smith: 2 wds. |
| 36% | MISS | 4 | & 22A 2000 action-comedy film starring Sandra Bullock and Michael Caine |
| 36% | ROLEMODELS | 10 | 2008 comedy starring Paul Rudd and Seann William Scott: 2 wds. |
| 36% | RUNAWAYBRIDE | 12 | 1999 romantic comedy starring Julia Roberts and Richard Gere: 2 wds. |
| 36% | OHGOD | 5 | 1977 film comedy starring John Denver and George Burns: 2 wds. |