| 100% | EURO | 4 | 21st-century currency |
| 78% | DORA | 4 | 21st century explorer |
| 77% | LASERMOUSE | 10 | 21st century gaming accessory |
| 73% | IMS | 3 | Contacts 21st century-style |
| 71% | UPDATE | 6 | Bring into the 21st century |
| 71% | MMI | 3 | Start of the 21st century |
| 69% | DOTCOMEXPLOSION | 15 | Boom of the early 21st century |
| 69% | OBAMACRAT | 9 | Certain liberal of the 21st century |
| 66% | CIRQUE | 6 | __ du soleil, traveling show for the 21st century |
| 64% | NOAH | 4 | "21 Lessons for the 21st Century" author Yuval ___ Harari |
| 62% | DATASCIENTIST | 13 | "Sexiest job of the 21st century," per Harvard Business Review |
| 62% | BROKEBACKMOUNTAIN | 17 | Couple in the 21st century with Best Director Oscar winners |
| 61% | LORDE | 5 | "The 21st century's author of adolescent evolution," per Cyrena Touros |
| 60% | NEW | 3 | 21st-century |
| 59% | SAMUELALITO | 11 | Second Supreme Court justice confirmed in the 21st century (2006): 2 wds. |
| 59% | SONIASOTOMAYOR | 14 | Third Supreme Court justice confirmed in the 21st century (2009): 2 wds. |
| 59% | JOHNROBERTS | 11 | First Supreme Court justice confirmed in the 21st century (2005): 2 wds. |
| 59% | MML | 3 | 21st-century year |
| 57% | THESWINEFLU | 11 | 21st-century epidemic concern |
| 57% | LAURA | 5 | 21st-century first lady |
| 57% | OPIOIDS | 7 | 21st-century health menace |
| 57% | AMISH | 5 | 21st-century buggy drivers |
| 57% | OBAMAS | 6 | 21st-century first family |
| 55% | BIDEN | 5 | 21st-century vice president Joe |
| 53% | GEOCACHING | 10 | 21st-century pastime for treasure hunters |
| 53% | MMLI | 4 | Mid 21st-century date |
| 52% | REDSOX | 6 | One of two MLB teams with three World Series titles in the 21st century (2 wds.) |
| 51% | DAY | 3 | Green ___ ("21st Century Breakdown" band) |
| 50% | OBAMA | 5 | 21st-century president with a Nobel Peace Prize |
| 46% | MEAD | 4 | Ancient alcoholic beverage enjoying a 21st-century resurgence |