| 100% | HIGHFIDELITY | 12 | 50-Across novel that was adapted into a feature film in 2000, a Broadway musical in 2006, and a TV series in 2020 (2 wds.) |
| 47% | HANDMAIDSTALE | 13 | Margaret Atwood's dystopian novel, "The ___" which has been adapted into a film, an opera and a TV series: 2 wds. |
| 45% | OLDMAN | 6 | *"The ___ and the Sea," 1952 novel by Ernest Hemingway that was adapted into a 1958 film: 2 wds. |
| 45% | WOMENTALKING | 12 | Novel by 36-Across about an isolated Mennonite community in Bolivia that was adapted by 17-Across into a film starring Frances McDormand, Claire Foy, and Rooney Mara (2 wds.) |
| 44% | THENOTEBOOK | 11 | 2004 romantic drama starring 18-Across and 32-Across that was adapted as a Broadway musical in 2024 (2 wds.) |
| 41% | NAUGHTYDOG | 10 | Video game company that created the "Uncharted" action-adventure game series, which has been adapted into a film starring Antonio Banderas, 31-Across, and 43-Across (2 wds.) |
| 41% | AIDA | 4 | Opera that was adapted into a musical that opened on Broadway in 2000 |
| 40% | DEADMANSWALK | 12 | Novel in 32-Across's "Lonesome Dove" adventure series that was adapted as a TV miniseries (3 wds.) |
| 40% | TWILIGHT | 8 | 2005 novel by Stephenie Meyer featuring vampires that was adapted into a film series starring Robert Pattinson |
| 40% | LIES | 4 | "Big Little ___," novel by Liane Moriarty that was adapted into a TV series starring Reese Witherspoon and Meryl Streep |
| 39% | THEPRODUCERS | 12 | Mel Brooks film of 1967 adapted into a 2001 Broadway musical and 2005 movie musical: 2 wds. |
| 38% | IKNOWWHATYOU | 12 | With 30-Across, Lois Duncan horror novel that was turned into a film in 1997: 4 wds. |
| 38% | FIREFLYLANE | 11 | Bestselling novel by Kristin Hannah about two lifelong best friends that was adapted as a Netflix series starring 19-Across and 32-Across (2 wds.) |
| 37% | THENAMESAKE | 11 | Debut novel by 25-Across/27-Across that was adapted as a film starring Kal Penn and directed by Mira Nair (2 wds.) |
| 37% | NAKEDSUN | 8 | "The ___," 1957 sci-fi novel by Isaac Asimov that was adapted into an episode of the TV series "Out of the Unknown": 2 wds. |
| 37% | THEORIENT | 9 | "Murder on ___ Express," Agatha Christie's detective novel published in 1934, which was adapted into a film starring Kenneth Branagh in 2017: 2 wds. |
| 37% | NATIVESON | 9 | Best-selling 1940 novel that was adapted into a film, with its author playing the protagonist, in 1951 |
| 37% | LAURALIPPMAN | 12 | Author of the 2019 novel "Lady in the Lake," which was adapted into an Apple TV+ miniseries starring 19-Across and 34-Across (2 wds.) |
| 37% | DEATHONTHENILE | 14 | Novel by 19-Across set in Egypt adapted into a 2022 film starring and directed by 33-Across (4 wds.) |
| 36% | WHITENOISE | 10 | Novel by 44-Across that was adapted as a 2022 film by Noah Baumbach (2 wds.) |
| 36% | ROAD | 4 | "The ___," 2006 novel by Cormac McCarthy that was adapted into a 2009 survival film |
| 36% | THEDRY | 6 | Novel by Australian author Jane Harper that was adapted into a movie starring Eric Bana: 2 wds. |
| 36% | CALEBCARR | 9 | Writer whose novels "The Alienist" and "The Angel of Darkness" were adapted as a TV series starring 16-Across and 32-Across (2 wds.) |
| 36% | AMORTOWLES | 10 | "The Lincoln Highway" writer whose novel "A Gentleman in Moscow" was adapted as a Paramount+ series starring 14-Across and 45-Across (2 wds.) |
| 36% | MAGICLESSONS | 12 | 2020 novel by 46-Across that's a prequel to her 1995 novel adapted as a film starring Sandra Bullock and Nicole Kidman (2 wds.) |
| 35% | LEGEND | 6 | "I Am ___," 1954 horror novel by Richard Matheson featuring vampires that was adapted into a film starring Will Smith |
| 35% | SCOTT | 5 | "___ Pilgrim," series of graphic novels by Bryan Lee O'Malley that was adapted into a film starring Michael Cera |
| 35% | SHUTTERISLAND | 13 | 2003 18-Across novel about a mental hospital that was made into a 2010 Leonardo DiCaprio film: 2 wds. |
| 35% | DAVINCI | 7 | "The ___ Code," 2003 novel by Dan Brown that was made into a film: 2 wds. |
| 35% | RICHARDFORD | 11 | "The Sportswriter" novelist whose novel 47-Across was adapted into a film by 14-Across (2 wds.) |